MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction.
Journal
European journal of histochemistry : EJH
ISSN: 2038-8306
Titre abrégé: Eur J Histochem
Pays: Italy
ID NLM: 9207930
Informations de publication
Date de publication:
16 Apr 2020
16 Apr 2020
Historique:
received:
23
01
2020
accepted:
27
03
2020
entrez:
22
4
2020
pubmed:
22
4
2020
medline:
11
11
2020
Statut:
epublish
Résumé
Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.
Identifiants
pubmed: 32312031
doi: 10.4081/ejh.2020.3113
pmc: PMC7171425
doi:
Substances chimiques
Biomarkers
0
MMP7 protein, human
EC 3.4.24.23
Matrix Metalloproteinase 7
EC 3.4.24.23
MMP9 protein, human
EC 3.4.24.35
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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