A Modular Vaccine Platform Combining Self-Assembled Peptide Cages and Immunogenic Peptides.
coiled coils
peptide design
self‐assembly
subunit vaccines
synthetic biology
Journal
Advanced functional materials
ISSN: 1616-301X
Titre abrégé: Adv Funct Mater
Pays: Germany
ID NLM: 101190390
Informations de publication
Date de publication:
21 Feb 2019
21 Feb 2019
Historique:
received:
18
10
2018
revised:
18
12
2018
entrez:
22
4
2020
pubmed:
21
2
2019
medline:
21
2
2019
Statut:
ppublish
Résumé
Subunit vaccines use delivery platforms to present minimal antigenic components for immunization. The benefits of such systems include multivalency, self-adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self-assembling peptide cages (SAGEs) have been reported. In these, de novo peptides are combined to make hubs that assemble into nanoparticles when mixed in aqueous solution. Here it is shown that SAGEs are nontoxic particles with potential as accessible synthetic peptide scaffolds for the delivery of immunogenic components. To this end, SAGEs functionalized with the model antigenic peptides tetanus toxoid
Identifiants
pubmed: 32313545
doi: 10.1002/adfm.201807357
pii: ADFM201807357
pmc: PMC7161841
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1807357Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L01386X/1
Pays : United Kingdom
Informations de copyright
© 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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Adv Funct Mater. 2019 Feb 21;29(8):1807357
pubmed: 32313545