Investigation of the Protective Effect of Nigella Sativa Oil in Cisplatin Induced Oral Mucositis: An Experimental Study.
Nigella sativa oil
animal experimentation
cisplatin
oral mucositis
Journal
Turkish archives of otorhinolaryngology
ISSN: 2667-7474
Titre abrégé: Turk Arch Otorhinolaryngol
Pays: Turkey
ID NLM: 101682806
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
accepted:
16
12
2019
entrez:
22
4
2020
pubmed:
22
4
2020
medline:
22
4
2020
Statut:
ppublish
Résumé
The aim of this experimental study was to investigate the histopathologic effect of Nigella Sativa oil (NSO) on cisplatin (Cis) induced oral mucositis (OM) in rats. Twenty-four rats were divided into four equal groups. The animals in Group 1 and Group 2 were given 5 mg/kg intraperitoneal (ip) Cis systemically on the 1 The mean mucosal thicknesses of the groups were 224.58 μm, 276.1 μm, 323.33 μm, and 331.33 μm, respectively for Groups 1, 2, 3, and 4 (p<0.05). When the degree of mucosal inflammation was examined, the most intense inflammation was detected in Group 1 and the least intense inflammation was in Group 4 (p<0.01). The degree of inflammation in Group 2 and Group 3 were similar to Group 4 (p>0.05). According to the results of this study, NSO, for which anti-inflammatory and antioxidant properties have been shown in previous studies, may also be effective in preventing Cis-induced OM.
Identifiants
pubmed: 32313889
doi: 10.5152/tao.2020.4733
pii: tao-58-1-10
pmc: PMC7162592
doi:
Types de publication
Journal Article
Langues
eng
Pagination
10-15Informations de copyright
© Copyright 2020 by Official Journal of the Turkish Society of Otorhinolaryngology and Head and Neck Surgery.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no conflicts of interest to declare.
Références
J Craniofac Surg. 2018 May;29(3):e279-e282
pubmed: 29381633
Int J Pediatr Otorhinolaryngol. 2003 Feb;67(2):133-9
pubmed: 12623149
Otolaryngol Head Neck Surg. 2016 Jan;154(1):144-9
pubmed: 26419839
Oral Oncol. 2007 Apr;43(4):395-401
pubmed: 16979925
J Pharm Belg. 1998 Mar-Apr;53(2):87-93; discussion 93-5
pubmed: 9609969
Int J Radiat Biol. 2014 Oct;90(10):884-91
pubmed: 24827853
Curr Oral Health Rep. 2015;2(4):202-211
pubmed: 26523246
Arch Otolaryngol Head Neck Surg. 2001 Nov;127(11):1353-6
pubmed: 11701073
Phytomedicine. 2002 Jan;9(1):69-74
pubmed: 11924767
Ann Oncol. 2010 May;21 Suppl 5:v184-6
pubmed: 20555077
Cells. 2016 Mar 29;5(2):
pubmed: 27043634
J Pharmacol Sci. 2015 Mar;127(3):339-43
pubmed: 25837932
Acta Otolaryngol. 2004 May;124(4):421-6
pubmed: 15224867
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):702-8
pubmed: 24080533
Eurasian J Med. 2019 Oct;51(3):247-251
pubmed: 31692618
Support Care Cancer. 2019 Oct;27(10):3985-3995
pubmed: 31286230
PLoS One. 2017 Oct 23;12(10):e0186511
pubmed: 29059216
Int J Pediatr Otorhinolaryngol. 2016 Sep;88:52-7
pubmed: 27497387
Medicina (Kaunas). 2019 Jan 22;55(2):
pubmed: 30678228
Hear Res. 2003 Jul;181(1-2):109-15
pubmed: 12855369
BMJ Support Palliat Care. 2017 Mar;7(1):7-16
pubmed: 25818385
J Oral Pathol Med. 2017 Oct;46(9):680-688
pubmed: 28075506
PLoS One. 2016 Sep 15;11(9):e0162106
pubmed: 27632426