The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism.
autism
autism-related traits
high familial risk
parental age
Journal
Autism research : official journal of the International Society for Autism Research
ISSN: 1939-3806
Titre abrégé: Autism Res
Pays: United States
ID NLM: 101461858
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
10
12
2019
revised:
20
03
2020
accepted:
24
03
2020
pubmed:
22
4
2020
medline:
5
6
2021
entrez:
22
4
2020
Statut:
ppublish
Résumé
Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age < 30 years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14-7.02). Likewise, younger age (<30 years) for both parents was associated with decreases in Mullen Scales of Early Learning early learning composite (MSEL-ELC) scores (adjusted β = -9.62, 95% CI = -17.1 to -2.15). We also found significant increases in cognitive functioning based on MSEL-ELC scores with increasing paternal age (adjusted β associated with a 10-year increase in paternal age = 5.51, 95% CI = 0.70-10.3). Results suggest the potential for a different relationship between parental age and ASD-related outcomes in families with elevated ASD risk than has been observed in general population samples. Autism Res 2020, 13: 998-1010. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous work suggests that older parents have a greater likelihood of having a child with autism. We investigated this relationship in the younger siblings of families who already had a child with autism. In this setting, we found a higher likelihood of autism, as well as poorer cognitive scores, in the siblings with younger fathers, and higher cognitive scores in the siblings with older parents. These results suggest that parental age associations may differ based on children's familial risk for autism.
Identifiants
pubmed: 32314879
doi: 10.1002/aur.2303
pmc: PMC7396152
mid: NIHMS1610966
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
998-1010Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103524
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD057284
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES023513
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025574
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH059630
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD086984
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023342
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES028533
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD055741
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES028089
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES020392
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103573
Pays : United States
Informations de copyright
© 2020 International Society for Autism Research, Wiley Periodicals, Inc.
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