A salt-induced kinase is required for the metabolic regulation of sleep.
Adenosine Triphosphate
/ metabolism
Animals
Animals, Genetically Modified
Caenorhabditis elegans
/ metabolism
Caenorhabditis elegans Proteins
/ genetics
Cell Nucleus
/ metabolism
Energy Metabolism
/ genetics
Histone Deacetylases
/ genetics
Mutation
Neuroendocrine Cells
/ metabolism
Protein Serine-Threonine Kinases
/ genetics
Sensory Receptor Cells
/ metabolism
Sleep
/ physiology
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
05
03
2019
accepted:
20
03
2020
entrez:
22
4
2020
pubmed:
22
4
2020
medline:
28
7
2020
Statut:
epublish
Résumé
Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During Caenorhabditis elegans sleep, energetic stores are allocated to nonneural tasks with a resultant drop in the overall fat stores and energy charge. Mutants lacking KIN-29, the C. elegans homolog of a mammalian Salt-Inducible Kinase (SIK) that signals sleep pressure, have low ATP levels despite high-fat stores, indicating a defective response to cellular energy deficits. Liberating energy stores corrects adiposity and sleep defects of kin-29 mutants. kin-29 sleep and energy homeostasis roles map to a set of sensory neurons that act upstream of fat regulation as well as of central sleep-controlling neurons, suggesting hierarchical somatic/neural interactions regulating sleep and energy homeostasis. Genetic interaction between kin-29 and the histone deacetylase hda-4 coupled with subcellular localization studies indicate that KIN-29 acts in the nucleus to regulate sleep. We propose that KIN-29/SIK acts in nuclei of sensory neuroendocrine cells to transduce low cellular energy charge into the mobilization of energy stores, which in turn promotes sleep.
Identifiants
pubmed: 32315298
doi: 10.1371/journal.pbio.3000220
pii: PBIOLOGY-D-19-00628
pmc: PMC7173979
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Adenosine Triphosphate
8L70Q75FXE
kin-29 protein, C elegans
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
HDA-4 protein, C elegans
EC 3.5.1.-
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3000220Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103650
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088432
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107969
Pays : United States
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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