Cognitive impairment in angiographically negative subarachnoid haemorrhage: A case-matched prospective study 1-year post-incident.
Angiographically negative subarachnoid haemorrhage
Cognition
Neuropsychology
Non-aneurysmal subarachnoid haemorrhage
Perimesencephalic subarachnoid haemorrhage
Subarachnoid haemorrhage of unknown origin
Subarachnoid hemorrhage
Journal
Cortex; a journal devoted to the study of the nervous system and behavior
ISSN: 1973-8102
Titre abrégé: Cortex
Pays: Italy
ID NLM: 0100725
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
30
08
2019
revised:
25
11
2019
accepted:
12
03
2020
pubmed:
22
4
2020
medline:
22
6
2021
entrez:
22
4
2020
Statut:
ppublish
Résumé
Few studies investigate cognitive outcomes in patients with angiographically negative subarachnoid haemorrhage (anSAH), which is traditionally viewed as a condition with an excellent prognosis. The aim of this study was to assess neuropsychological outcomes in a prospective cohort of anSAH patients 1-year post-event. This prospective case-controlled study of cognitive function in patients with anSAH (n = 38) recruited from the national centre for neurosurgery and compared matched controls (n = 28). The cognitive battery assessed memory, executive function, attention, visuo-spatial function, processing speed, social cognition, language, and mood. Patients were matched to controls on age, education, and premorbid intelligence. Multivariate Analysis of Variance (MANOVA) were used. Patients performed significantly worse than controls on all cognitive domain composite scores. anSAH patients had a higher frequency of impairment within encoding, executive, and processing speed domains when compared to healthy controls. Discriminant Function Analysis (DFA) indicated high sensitivity and specificity to detect cognitive impairment between groups. Although the majority of patients with anSAH make an excellent physical recovery, our data show a high rate of cognitive dysfunction in patients 1-year post-incident. Cognitive impairment in anSAH is not a universal feature, and its manifestations may be more heterogeneous than previously recognised. Some impairment may be mediated by impaired speed of processing which negatively influences other cognitive domains. The profile of cognitive impairment supports a neurotoxicity hypothesis, which suggests that blood in the subarachnoid space, rather than the bleed per se, results in a diffuse pattern of cognitive deficits.
Identifiants
pubmed: 32315835
pii: S0010-9452(20)30107-6
doi: 10.1016/j.cortex.2020.03.006
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-60Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.