Cytotoxicity of the Sesquiterpene Lactone Spiciformin and Its Acetyl Derivative against the Human Leukemia Cell Lines U-937 and HL-60.
Amino Acid Chloromethyl Ketones
/ pharmacology
Antineoplastic Agents
/ chemistry
Apoptosis
/ drug effects
Caspases
/ chemistry
Cell Line, Tumor
HL-60 Cells
Humans
Lactones
/ chemistry
Leukemia, Promyelocytic, Acute
/ metabolism
Membrane Potential, Mitochondrial
/ drug effects
Mitogen-Activated Protein Kinases
/ metabolism
Phosphorylation
/ drug effects
Poly(ADP-ribose) Polymerases
/ metabolism
Proto-Oncogene Proteins c-bcl-2
/ metabolism
Reactive Oxygen Species
/ metabolism
Sesquiterpenes
/ chemistry
Signal Transduction
/ drug effects
apoptosis
caspase
cytotoxicity
poly(ADP-ribose) polymerase
sesquiterpene lactone
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Apr 2020
16 Apr 2020
Historique:
received:
27
03
2020
revised:
10
04
2020
accepted:
14
04
2020
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
23
1
2021
Statut:
epublish
Résumé
Spiciformin (
Identifiants
pubmed: 32316340
pii: ijms21082782
doi: 10.3390/ijms21082782
pmc: PMC7215469
pii:
doi:
Substances chimiques
Amino Acid Chloromethyl Ketones
0
Antineoplastic Agents
0
Lactones
0
Proto-Oncogene Proteins c-bcl-2
0
Reactive Oxygen Species
0
Sesquiterpenes
0
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
0
Poly(ADP-ribose) Polymerases
EC 2.4.2.30
Mitogen-Activated Protein Kinases
EC 2.7.11.24
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agencia Canaria de Investigación, Innovación y Sociedad de la Información
ID : PROID2017010095 FEDER/ACIISI
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