In Vitro Differentiation of Human Skin-Derived Cells into Functional Sensory Neurons-Like.
TRP
adult stem cell
differentiation
sensory neuron
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
17 04 2020
17 04 2020
Historique:
received:
23
03
2020
revised:
13
04
2020
accepted:
14
04
2020
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
16
3
2021
Statut:
epublish
Résumé
Skin-derived precursor cells (SKPs) are neural crest stem cells that persist in certain adult tissues, particularly in the skin. They can generate a large type of cell in vitro, including neurons. SKPs were induced to differentiate into sensory neurons (SNs) by molecules that were previously shown to be important for the generation of SNs: purmorphamine, CHIR99021, BMP4, GDNF, BDNF, and NGF. We showed that the differentiation of SKPs induced the upregulation of neurogenins. At the end of the differentiation protocol, transcriptional analysis was performed on
Identifiants
pubmed: 32316463
pii: cells9041000
doi: 10.3390/cells9041000
pmc: PMC7226083
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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