Estrogen Receptors and Endometriosis.
endometriosis
estrogen receptors
modulation
treatment strategy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Apr 2020
17 Apr 2020
Historique:
received:
28
02
2020
revised:
10
04
2020
accepted:
15
04
2020
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
20
1
2021
Statut:
epublish
Résumé
Endometriosis is a frequent and chronic inflammatory disease with impacts on reproduction, health and quality of life. This disorder is highly estrogen-dependent and the purpose of hormonal treatments is to decrease the endogenous ovarian production of estrogens. High estrogen production is a consistently observed endocrine feature of endometriosis. mRNA and protein levels of estrogen receptors (ER) are different between a normal healthy endometrium and ectopic/eutopic endometrial lesions: endometriotic stromal cells express extraordinarily higher ERβ and significantly lower ERα levels compared with endometrial stromal cells. Aberrant epigenetic regulation such as DNA methylation in endometriotic cells is associated with the pathogenesis and development of endometriosis. Although there is a large body of data regarding ERs in endometriosis, our understanding of the roles of ERα and ERβ in the pathogenesis of endometriosis remains incomplete. The goal of this review is to provide an overview of the links between endometriosis, ERs and the recent advances of treatment strategies based on ERs modulation. We will also attempt to summarize the current understanding of the molecular and cellular mechanisms of action of ERs and how this could pave the way to new therapeutic strategies.
Identifiants
pubmed: 32316608
pii: ijms21082815
doi: 10.3390/ijms21082815
pmc: PMC7215544
pii:
doi:
Substances chimiques
ESR1 protein, human
0
ESR2 protein, human
0
Estrogen Receptor alpha
0
Estrogen Receptor beta
0
Receptors, Estrogen
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
HPB (Oxford). 2002;4(1):43-5
pubmed: 18333152
Endocrinology. 2011 Aug;152(8):3226-32
pubmed: 21586552
Int J Gynecol Cancer. 2016 Jan;26(1):199-207
pubmed: 26569057
Mol Hum Reprod. 2019 Sep 1;25(9):550-561
pubmed: 31323679
Semin Reprod Med. 2017 Jan;35(1):38-53
pubmed: 28002850
Gynecol Obstet Invest. 1999;47 Suppl 1:3-9; discussion 9-10
pubmed: 10087422
Fertil Steril. 2012 Nov;98(5):1200-8
pubmed: 22884659
Nat Cell Biol. 2019 Aug;21(8):1041-1051
pubmed: 31371824
Development. 2017 May 15;144(10):1775-1786
pubmed: 28442471
Endocrinology. 2008 Mar;149(3):1190-204
pubmed: 18048499
Rev Recent Clin Trials. 2012 Feb;7(1):47-70
pubmed: 21864249
Fertil Steril. 2004 May;81(5):1351-6
pubmed: 15136101
Gynecol Endocrinol. 2019 Jan;35(1):10-16
pubmed: 30044157
Nat Rev Dis Primers. 2018 Jul 19;4(1):9
pubmed: 30026507
Hum Reprod Update. 2009 Jul-Aug;15(4):441-61
pubmed: 19279046
J Pathol. 2011 Jun;224(2):261-9
pubmed: 21480232
Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):84-7
pubmed: 20188455
Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:567-584
pubmed: 27814026
Insights Imaging. 2018 Apr;9(2):149-172
pubmed: 29450853
Lancet. 2010 Aug 28;376(9742):730-8
pubmed: 20801404
Semin Reprod Med. 2012 Jan;30(1):39-45
pubmed: 22271293
Lancet. 2004 Nov 13-19;364(9447):1789-99
pubmed: 15541453
Fertil Steril. 2005 Aug;84(2):300-4
pubmed: 16084868
N Engl J Med. 2001 Jul 26;345(4):266-75
pubmed: 11474666
Reprod Biol Endocrinol. 2012 Apr 20;10:30
pubmed: 22520060
Fertil Steril. 1998 Apr;69(4):709-13
pubmed: 9548162
Endocrinology. 2018 Jan 1;159(1):103-118
pubmed: 28927243
Reprod Biol Endocrinol. 2013 Dec 11;11:112
pubmed: 24330552
Hum Reprod Update. 2014 Jul-Aug;20(4):467-84
pubmed: 24634322
Hum Reprod Update. 2016 Nov;22(6):762-774
pubmed: 27591248
Endocrinology. 2012 Aug;153(8):3960-71
pubmed: 22700766
Mol Hum Reprod. 1999 Aug;5(8):742-7
pubmed: 10421802
J Minim Invasive Gynecol. 2016 Jul-Aug;23(5):839-42
pubmed: 27130533
Am J Reprod Immunol. 2018 Nov;80(5):e13023
pubmed: 30010222
Arch Gynecol Obstet. 2016 May;293(5):1081-6
pubmed: 26385726
Nat Commun. 2017 Jun 15;8:15840
pubmed: 28643774
Mol Hum Reprod. 1999 Jul;5(7):651-5
pubmed: 10381820
Fertil Steril. 1997 May;67(5):817-21
pubmed: 9130884
Nat Cell Biol. 2017 May;19(5):568-577
pubmed: 28394884
Fertil Steril. 2011 Aug;96(2):366-373.e8
pubmed: 21718982
Cells. 2019 Sep 21;8(10):
pubmed: 31546660
Biol Reprod. 2014 Jun;90(6):121
pubmed: 24740602
Obstet Gynecol. 2008 Jan;111(1):88-96
pubmed: 18165396
Hum Reprod. 2017 Jul 1;32(7):1432-1438
pubmed: 28482063
J Ovarian Res. 2019 Feb 6;12(1):14
pubmed: 30728052
Physiol Rev. 2017 Jul 1;97(3):1045-1087
pubmed: 28539435
J Clin Endocrinol Metab. 1998 Dec;83(12):4474-80
pubmed: 9851796
Nat Rev Endocrinol. 2019 Nov;15(11):666-682
pubmed: 31488888
J Clin Endocrinol Metab. 1997 Dec;82(12):4258-65
pubmed: 9398750
Fertil Steril. 2007 Aug;88(2):462-71
pubmed: 17343855
Fertil Steril. 2001 Jun;75(6):1198-205
pubmed: 11384649
Fertil Steril. 2011 Oct;96(4):939-42
pubmed: 21868006
Expert Opin Pharmacother. 2013 Feb;14(3):291-305
pubmed: 23356536
Hum Reprod. 2005 Apr;20(4):936-41
pubmed: 15618247
Am J Pathol. 1927 Mar;3(2):93-110.43
pubmed: 19969738
Hum Reprod Update. 2018 Sep 1;24(5):577-598
pubmed: 29893860
Autoimmun Rev. 2018 Oct;17(10):945-955
pubmed: 30107265
J Clin Endocrinol Metab. 1997 Feb;82(2):600-6
pubmed: 9024261
J Reprod Immunol. 2013 Mar;97(1):95-103
pubmed: 23432876
Gynecol Endocrinol. 2019 May;35(5):390-394
pubmed: 30668182
Hum Reprod. 2006 Jul;21(7):1856-62
pubmed: 16517562
Int J Mol Sci. 2018 Jul 20;19(7):
pubmed: 30037059
J Psychosom Obstet Gynaecol. 2015;36(4):135-41
pubmed: 26328618
Hum Reprod. 2016 Jul;31(7):1475-82
pubmed: 27141041
Mol Endocrinol. 2014 Aug;28(8):1304-15
pubmed: 24992181
Fertil Steril. 2017 Mar;107(3):555-565
pubmed: 28139238
Sci Transl Med. 2015 Jan 21;7(271):271ra9
pubmed: 25609169
Fertil Steril. 1999 Dec;72(6):961-9
pubmed: 10593363
Endocr Rev. 2019 Aug 1;40(4):1048-1079
pubmed: 30994890
Reprod Sci. 2012 Jul;19(7):684-93
pubmed: 22378861
Fertil Steril. 2006 May;85(5):1307-18
pubmed: 16647373
N Engl J Med. 2009 Jan 15;360(3):268-79
pubmed: 19144942
J Obstet Gynaecol Res. 2019 Oct;45(10):2121-2127
pubmed: 31368157
Mol Aspects Med. 2006 Aug;27(4):299-402
pubmed: 16914190
Reprod Med Biol. 2019 Jun 18;18(4):305-311
pubmed: 31607790
Endocrinology. 2019 Nov 1;160(11):2495-2516
pubmed: 31504401
Arch Surg. 2009 Mar;144(3):234-9; discussion 239
pubmed: 19289662
J Clin Endocrinol Metab. 2009 Feb;94(2):615-22
pubmed: 19001520
Cell. 2015 Nov 5;163(4):960-74
pubmed: 26544941
Fertil Steril. 2016 May;105(5):1266-1273
pubmed: 26827666
Reproduction. 2016 Sep;152(3):R63-78
pubmed: 27165051
Maturitas. 2016 Apr;86:28-43
pubmed: 26921926
Annu Rev Physiol. 2005;67:285-308
pubmed: 15709960
JAMA. 2009 Sep 2;302(9):955-61
pubmed: 19724042
PLoS Genet. 2014 Mar 06;10(3):e1004158
pubmed: 24603652
Biomed Res Int. 2015;2015:795976
pubmed: 26247027
Endocrinology. 2003 Sep;144(9):3934-42
pubmed: 12933667
Biol Reprod. 2007 Oct;77(4):681-7
pubmed: 17625110
Fertil Steril. 2004 Jul;82(1):80-5
pubmed: 15236993