Simian Immunodeficiency Virus-Infected Memory CD4
Animals
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
Central Nervous System
/ immunology
Disease Models, Animal
Fluorescent Antibody Technique
Host-Pathogen Interactions
/ immunology
Immunohistochemistry
Immunophenotyping
Leukocytes, Mononuclear
/ immunology
Macrophages
/ immunology
Nervous System Diseases
/ etiology
Neuroimmunomodulation
Simian Acquired Immunodeficiency Syndrome
/ complications
Simian Immunodeficiency Virus
/ immunology
Viral Load
Virulence
AIDS
CD4 T cells
central nervous system infections
encephalitis
inflammation
macrophages
neuroAIDS
neuroimmunology
neurovirulence
rhesus macaque
simian immunodeficiency virus
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Simian immunodeficiency virus (SIV)-infected nonhuman primates can serve as a relevant model for AIDS neuropathogenesis. Current SIV-induced encephalitis (SIVE)/neurological complications of AIDS (neuroAIDS) models are generally associated with rapid progression to neuroAIDS, which does not reflect the tempo of neuroAIDS progression in humans. Recently, we isolated a neuropathogenic clone, SIVsm804E-CL757 (CL757), obtained from an SIV-infected rhesus macaque (RM). CL757 causes a more protracted progression to disease, inducing SIVE in 50% of inoculated animals, with high cerebral spinal fluid viral loads, multinucleated giant cells (MNGCs), and perivascular lymphocytic cuffing in the central nervous system (CNS). This latter finding is reminiscent of human immunodeficiency virus (HIV) encephalitis in humans but not generally observed in rapid progressor animals with neuroAIDS. Here, we studied which subsets of cells within the CNS were targeted by CL757 in animals with neurological symptoms of SIVE. Immunohistochemistry of brain sections demonstrated infiltration of CD4
Identifiants
pubmed: 32317323
pii: mBio.00602-20
doi: 10.1128/mBio.00602-20
pmc: PMC7175093
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
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