Therapeutic opportunities to manage COVID-19/SARS-CoV-2 infection: Present and future.
COVID-19
SARS-CoV-2
prophylaxis
therapy
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
28
4
2020
Statut:
ppublish
Résumé
A severe form of respiratory disease - COVID-19, caused by SARS-CoV-2 infection, has evolved into a pandemic resulting in significant morbidity and mortality. The unabated spread of the disease is due to lack of vaccine and effective therapeutic agents against this novel virus. Hence, the situation demands an immediate need to explore all the plausible therapeutic and prophylactic strategies that can be made available to stem the spread of the disease. Towards this effort, the current review outlines the key aspects of the pathobiology associated with the morbidity and mortality in COVID-19 patients, which includes a viral response phase and an exaggerated host response phase. The review also summarizes therapeutic agents that are currently being explored along with those with potential for consideration. The broad groups of therapeutic agents discussed include those that: (i) block viral entry to host cells, (ii) block viral replication and survival in host cells, and (iii) dampen exaggerated host immune response. The various kinds of pharmaceutical prophylactic options that may be followed to prevent COVID-19 have also been discussed.
Identifiants
pubmed: 32317431
pii: IndianJOphthalmol_2020_68_5_693_281523
doi: 10.4103/ijo.IJO_639_20
pmc: PMC7350468
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
693-702Déclaration de conflit d'intérêts
None
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