Control of cell colony growth by contact inhibition.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
received:
23
08
2019
accepted:
20
03
2020
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
27
11
2020
Statut:
epublish
Résumé
Contact inhibition is a cell property that limits the migration and proliferation of cells in crowded environments. Here we investigate the growth dynamics of a cell colony composed of migrating and proliferating cells on a substrate using a minimal model that incorporates the mechanisms of contact inhibition of locomotion and proliferation. We find two distinct regimes. At early times, when contact inhibition is weak, the colony grows exponentially in time, fully characterised by the proliferation rate. At long times, the colony boundary moves at a constant speed, determined only by the migration speed of a single cell and independent of the proliferation rate. Further, the model demonstrates how cell-cell alignment speeds up colony growth. Our model illuminates how simple local mechanical interactions give rise to contact inhibition, and from this, how cell colony growth is self-organised and controlled on a local level.
Identifiants
pubmed: 32317692
doi: 10.1038/s41598-020-62913-z
pii: 10.1038/s41598-020-62913-z
pmc: PMC7174381
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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