Retinal phototoxicity and the evaluation of the blue light hazard of a new solid-state lighting technology.
Animals
Biomarkers
/ metabolism
Color
Dose-Response Relationship, Radiation
Gallium
/ chemistry
Gene Expression
/ radiation effects
Glial Fibrillary Acidic Protein
/ genetics
Humans
Light
/ adverse effects
Lighting
Luminescent Agents
/ chemistry
Male
Mitochondria
/ metabolism
Oxidative Stress
Primates
Radiometry
Rats
Rats, Wistar
Retinal Pigment Epithelium
/ metabolism
Species Specificity
Superoxide Dismutase
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
received:
19
09
2019
accepted:
28
03
2020
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
1
12
2020
Statut:
epublish
Résumé
Exposure Limit Values (ELV) for artificial lighting were defined in order to prevent light-induced damage to the retina. The evaluation of the lighting devices include the correction of their spectra by the B(λ) function or blue light hazard function, representing the relative spectral sensitivity of the human eye to the blue light. This weighting function peaks between 435 and 440 nm. In this study we evaluate a new generation of light emitting diode (LED), the GaN-on-GaN (gallium nitride on gallium nitride) LED, that present an emission peak in the purple part of the spectrum. Wistar rats were exposed to GaN-on-GaN and conventional diodes at different retinal doses (from 2.2 to 0.5 J/cm
Identifiants
pubmed: 32317708
doi: 10.1038/s41598-020-63442-5
pii: 10.1038/s41598-020-63442-5
pmc: PMC7174369
doi:
Substances chimiques
Biomarkers
0
GFAP protein, rat
0
Glial Fibrillary Acidic Protein
0
Luminescent Agents
0
gallium nitride
1R9CC3P9VL
Gallium
CH46OC8YV4
Superoxide Dismutase
EC 1.15.1.1
superoxide dismutase 2
EC 1.15.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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