Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.
P. aeruginosa
commensals
infection
keratritis
macrophages
neutrophils
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
12
2019
accepted:
10
03
2020
entrez:
23
4
2020
pubmed:
23
4
2020
medline:
27
3
2021
Statut:
epublish
Résumé
Why ocular mucosa is paucibacterial is unknown. Many different mechanisms have been suggested but the comprehensive experimental studies are sparse. We found that a deficiency in L-plastin (LCP1), an actin bundling protein, resulted in an ocular commensal overgrowth, characterized with increased presence of conjunctival
Identifiants
pubmed: 32318063
doi: 10.3389/fimmu.2020.00547
pmc: PMC7147296
doi:
Substances chimiques
Microfilament Proteins
0
Lcp1 protein, mouse
128868-76-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
547Subventions
Organisme : NEI NIH HHS
ID : R01 EY021798
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY005722
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029727
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI104732
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY022054
Pays : United States
Informations de copyright
Copyright © 2020 Lu, Kugadas, Smith-Page, Lamb, Lin, Ru, Morley, Fichorova, Mittal, Chauhan, Littleton, Saban and Gadjeva.
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