PI3K/AKT/mTOR pathway and autophagy regulator genes in paranasal squamous cell carcinoma metastasis.
Aged
Autophagy
/ genetics
Carcinoma, Squamous Cell
/ genetics
Cell Proliferation
/ genetics
Female
Humans
Male
Middle Aged
Neoplasm Metastasis
/ genetics
Paranasal Sinus Neoplasms
/ genetics
Phosphatidylinositol 3-Kinases
/ metabolism
Proto-Oncogene Proteins c-akt
/ metabolism
Signal Transduction
/ genetics
TOR Serine-Threonine Kinases
/ metabolism
Autophagy
Metastasis
PI3K/AKT/mTOR
Paranasal squamous cell carcinoma
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
21
01
2020
accepted:
11
04
2020
pubmed:
23
4
2020
medline:
12
2
2021
entrez:
23
4
2020
Statut:
ppublish
Résumé
Although there are many studies on the role of PI3K/AKT/mTOR pathway and autophagy genes in the mechanism of head and neck cancer formation and prognostic significance, there is no study investigating the role of the genes in paranasal sinus carcinomas. The aim of the study was to assess the role of the PI3K/AKT/mTOR pathway and autophagy related gene expression changes in squamous cell carcinoma of paranasal sinuses with and without neck metastasis. Eight paranasal squamous cell carcinoma patients (five without and three with neck metastasis) were included. Tissues were obtained during the surgery. Total RNA was isolated from the tissues and cDNA synthesis was performed. Expression levels of the genes were determined using qRT-PCR method. The results were evaluated using the 2
Identifiants
pubmed: 32319010
doi: 10.1007/s11033-020-05458-8
pii: 10.1007/s11033-020-05458-8
doi:
Substances chimiques
MTOR protein, human
EC 2.7.1.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM