Evaluation of the efficacy of topical sucralfate on healing haemorrhoidectomy incision wounds and reducing pain severity: A randomised clinical trial.
Administration, Topical
Adult
Aged
Aged, 80 and over
Analgesics
/ administration & dosage
Anti-Ulcer Agents
/ therapeutic use
Double-Blind Method
Female
Hemorrhoidectomy
/ adverse effects
Humans
Iran
Male
Middle Aged
Ointments
/ administration & dosage
Pain, Postoperative
/ drug therapy
Sucralfate
/ administration & dosage
Treatment Outcome
Wound Healing
/ drug effects
epithelialisation
haemorrhoidectomy
sucralfate
wound healing
Journal
International wound journal
ISSN: 1742-481X
Titre abrégé: Int Wound J
Pays: England
ID NLM: 101230907
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
10
12
2019
revised:
28
03
2020
accepted:
29
03
2020
pubmed:
23
4
2020
medline:
3
6
2021
entrez:
23
4
2020
Statut:
ppublish
Résumé
The healing of haemorrhoidectomy wounds is a main concern of surgeons and patients. Various modalities can improve the quality of wound care after surgery. Antibiotics and topical agents, such as solutions and ointments, have been evaluated. The current research investigates the effects of sucralfate ointment on wound healing (epithelialisation) and postoperative pain after open haemorrhoidectomy. This trial involves two groups of randomly collected patients (n = 40) who underwent open haemorrhoidectomy surgery by the Milligan-Morgan method. A 10% topical sucralfate ointment was applied to the investigated group's wounds, while the control group patients used Vaseline as a placebo. The present work measured the two outcomes as follows: pain severity by a Visual Analogues Scale (VAS) score and epithelialisation by a surgeon's visual inspection. During the postoperative phase, the mean VAS was 3.70 for the investigated group and 6.90 for the control group. On the average, the completion of epithelialisation for the investigated group was on day 13 as opposed to day 20 for the control group. The topical application of sucralfate ointment on post-haemorrhoidectomy wound is an effective method for the promotion of healing, also lessens the severity of pain, and reduces the need for analgesics.
Identifiants
pubmed: 32319175
doi: 10.1111/iwj.13369
pmc: PMC7948644
doi:
Substances chimiques
Analgesics
0
Anti-Ulcer Agents
0
Ointments
0
Sucralfate
54182-58-0
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
1047-1051Subventions
Organisme : Birjand University of Medical Sciences
Informations de copyright
© 2020 Medicalhelplines.com Inc and John Wiley & Sons Ltd.
Références
Reg Anesth Pain Med. 2003 May-Jun;28(3):228-32
pubmed: 12772141
Arch Dermatol. 1999 May;135(5):529-32
pubmed: 10328192
Int J Surg. 2016 Dec;36(Pt A):13-17
pubmed: 27765686
Int Wound J. 2020 Aug;17(4):1047-1051
pubmed: 32319175
Indian J Surg. 2010 Aug;72(4):294-7
pubmed: 21938191
Dis Colon Rectum. 1959 Mar-Apr;2(2):176-9
pubmed: 13652788
Recent Pat Inflamm Allergy Drug Discov. 2010 Jan;4(1):25-36
pubmed: 19832693
Dis Colon Rectum. 1998 Feb;41(2):159-64
pubmed: 9556238
Pak J Med Sci. 2013 Jan;29(1):122-7
pubmed: 24353522
J Pediatr Surg. 1991 Nov;26(11):1279-81
pubmed: 1812256
Dis Colon Rectum. 2008 Feb;51(2):231-4
pubmed: 18095028
World J Surg. 2013 Jan;37(1):233-8
pubmed: 23010700