Genetic polymorphisms of IL1RN were associated with lumbar disk herniation risk in a Chinese Han population.

Adult Aged China Female Humans Interleukin 1 Receptor Antagonist Protein / genetics Intervertebral Disc Displacement / genetics Lumbosacral Region / pathology Male Middle Aged Polymorphism, Single Nucleotide
IL-1 receptor antagonist (IL1RN) Lumbar disk herniation (LDH) case-control study gene polymorphisms

Journal

Molecular genetics & genomic medicine
ISSN: 2324-9269
Titre abrégé: Mol Genet Genomic Med
Pays: United States
ID NLM: 101603758

Informations de publication

Date de publication:
06 2020
Historique:
received: 25 12 2019
revised: 07 02 2020
accepted: 24 02 2020
pubmed: 23 4 2020
medline: 14 4 2021
entrez: 23 4 2020
Statut: ppublish

Résumé

Interleukin (IL)-1 is a cytokine superfamily, which involved in the inflammatory process and immune response in human body. IL-1 receptor antagonist (IL1RN) has been found to be associated with risk of lumbar disk herniation (LDH) in Finland samples. However, to date, there was no investigation focus on the polymorphisms of IL1RN in Chinese Han LDH patient. We conducted a case-control study based on 498 LDH patients and 463 controls. Five single-nucleotide polymorphisms (SNPs) in IL1RN were genotyped. As a result, we found that the AG and GG genotypes of rs3181052 were associated with decreased risk LDH under the dominant model (OR = 0.74, 95%CI: 0.57-0.96, p = .025). In the stratification analysis, the frequency of the "A" allele of rs17042888 was significantly lower in elder LDH cases than in controls (OR = 0.723, 95%CI: 0.544-0.961, p = .025). In addition, the AG and AA genotypes of rs17042888 were associated with decreased risk of LDH in elder group under the dominant model (OR = 0.69, 95%CI: 0.49-0.98, p = .038). The GG genotype of rs315919 was identified have correlation with decreased risk of LDH in elder group under the recessive model (OR = 0.60, 95%CI: 0.37-0.97, p = .034). Our data showed that IL1RN may be a susceptibility gene for risk of LDH in Chinese Han population.

Sections du résumé

BACKGROUND
Interleukin (IL)-1 is a cytokine superfamily, which involved in the inflammatory process and immune response in human body. IL-1 receptor antagonist (IL1RN) has been found to be associated with risk of lumbar disk herniation (LDH) in Finland samples. However, to date, there was no investigation focus on the polymorphisms of IL1RN in Chinese Han LDH patient.
MATERIALS AND METHODS
We conducted a case-control study based on 498 LDH patients and 463 controls. Five single-nucleotide polymorphisms (SNPs) in IL1RN were genotyped.
RESULTS
As a result, we found that the AG and GG genotypes of rs3181052 were associated with decreased risk LDH under the dominant model (OR = 0.74, 95%CI: 0.57-0.96, p = .025). In the stratification analysis, the frequency of the "A" allele of rs17042888 was significantly lower in elder LDH cases than in controls (OR = 0.723, 95%CI: 0.544-0.961, p = .025). In addition, the AG and AA genotypes of rs17042888 were associated with decreased risk of LDH in elder group under the dominant model (OR = 0.69, 95%CI: 0.49-0.98, p = .038). The GG genotype of rs315919 was identified have correlation with decreased risk of LDH in elder group under the recessive model (OR = 0.60, 95%CI: 0.37-0.97, p = .034).
CONCLUSIONS
Our data showed that IL1RN may be a susceptibility gene for risk of LDH in Chinese Han population.

Identifiants

DOI: 10.1002/mgg3.1247 PMID: 32319224 PMC: PMC7284030
pubmed: 32319224
doi: 10.1002/mgg3.1247
pmc: PMC7284030
doi:

Substances chimiques

IL1RN protein, human 0
Interleukin 1 Receptor Antagonist Protein 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1247

Informations de copyright

© 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.

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Auteurs

Ariga Tai (A)

Department of rehabilitation medicine, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Ming Zhu (M)

College of Mongolian medicine, Inner Mongolia Medical University, Hohhot, China.

Han Qilimuge (H)

College of Mongolian medicine, Inner Mongolia Medical University, Hohhot, China.

Hao Rong (H)

Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang, China.

Xue He (X)

Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang, China.

Mei Bai (M)

Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang, China.

Tianbo Jin (T)

Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, China.
ORCID: 0000-0003-0037-7900

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genetic polymorphisms of IL1RN were associated...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genetic polymorphisms of IL1RN were associated...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Genetic polymorphisms of IL1RN were associated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic polymorphisms of IL1RN were associated...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Antagoniste du récepteur à l'interleukine-1 › Genetic polymorphisms of IL1RN were associated...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hernie › Déplacement de disque intervertébral › Genetic polymorphisms of IL1RN were associated...
questionsmedicales.fr › Régions du corps › Tronc › Dos › Région lombosacrale › Genetic polymorphisms of IL1RN were associated...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genetic polymorphisms of IL1RN were associated...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genetic polymorphisms of IL1RN were associated...