A novel split mode TFBAR device for quantitative measurements of prostate specific antigen in a small sample of whole blood.

Acoustics Biosensing Techniques / instrumentation Humans Immunoassay Limit of Detection Male Point-of-Care Testing Prostate-Specific Antigen / blood

Journal

Nanoscale
ISSN: 2040-3372
Titre abrégé: Nanoscale
Pays: England
ID NLM: 101525249

Informations de publication

Date de publication:
07 May 2020
Historique:
pubmed: 23 4 2020
medline: 11 3 2021
entrez: 23 4 2020
Statut: ppublish

Résumé

Easy monitoring of prostate specific antigen (PSA) directly from blood samples would present a significant improvement as compared to conventional diagnostic methods. In this work, a split mode thin film bulk acoustic resonator (TFBAR) device was employed for the first time for label-free measurements of PSA concentrations in the whole blood and without sample pre-treatment. The surface of the sensor was covalently modified with anti-PSA antibodies and demonstrated a very high sensitivity of 101 kHz mL ng

Identifiants

DOI: 10.1039/d0nr00416b PMID: 32319508
pubmed: 32319508
doi: 10.1039/d0nr00416b
doi:

Substances chimiques

Prostate-Specific Antigen EC 3.4.21.77

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9647-9652

Subventions

Organisme : Cancer Research UK
ID : A20976
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_16040
Pays : United Kingdom

Auteurs

Ewelina Wajs (E)

Electrical Engineering, University of Cambridge, 9 JJ Thomson Avenue, Cambridge, CB3 0FA, UK. ewelina.wajs@icfo.eu.

Girish Rughoobur (G)

Keith Burling (K)

Anne George (A)

Andrew J Flewitt (AJ)

Vincent J Gnanapragasam (VJ)

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Classifications MeSH

questionsmedicales.fr › Disciplines des sciences naturelles › Physique › Acoustique › A novel split mode TFBAR device for...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › A novel split mode TFBAR device for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A novel split mode TFBAR device for...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › A novel split mode TFBAR device for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Limite de détection › A novel split mode TFBAR device for...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Systèmes automatisés lit malade › Analyse sur le lieu d'intervention › A novel split mode TFBAR device for...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Antigène spécifique de la prostate › A novel split mode TFBAR device for...