Bioaccessibility of Nickel and Cobalt Released from Occupationally Relevant Alloy and Metal Powders at Simulated Human Exposure Scenarios.
alloy powders
alloying effects
cobalt
corrosion
hazard classification
metal release
nickel
simulated human exposure
Journal
Annals of work exposures and health
ISSN: 2398-7316
Titre abrégé: Ann Work Expo Health
Pays: England
ID NLM: 101698454
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
10
12
2019
revised:
29
02
2020
accepted:
02
04
2020
pubmed:
23
4
2020
medline:
26
1
2021
entrez:
23
4
2020
Statut:
ppublish
Résumé
Nickel (Ni) and cobalt (Co) release from chromium-alloy powders (different stainless steels and a nickel-based Inconel alloy) compared with Ni and Co metal powders was investigated at simulated human exposure scenarios (ingestion, skin contact, and inhalation) between 2 and 168 h. All investigated powders consisted of particles sized within the respirable range. The powder particles and their surface reactivity were studied by means of nitrogen adsorption and electrochemical, spectroscopic (X-ray photoelectron spectroscopy and atomic absorption spectroscopy), light scattering, and microscopic techniques. The release of both Ni and Co was highest in the acidic and complexing fluids simulating the gastric environment and an inhalation scenario of small powders (artificial lysosomal fluid). Relatively high corrosion resistance and lower levels of released Ni and Co were observed in all fluids for all alloy powders compared with the corresponding pure metals. The extent of released metals was low for powders with a passive surface oxide. This study strongly emphasizes the importance of considering alloying effects in toxicological classification and/or regulation of Ni and Co in alloys and metals.
Identifiants
pubmed: 32320011
pii: 5823825
doi: 10.1093/annweh/wxaa042
pmc: PMC7328476
doi:
Substances chimiques
Alloys
0
Powders
0
Cobalt
3G0H8C9362
Nickel
7OV03QG267
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
659-675Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.
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