Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.


Journal

Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860

Informations de publication

Date de publication:
05 2020
Historique:
received: 31 01 2020
accepted: 03 02 2020
entrez: 23 4 2020
pubmed: 23 4 2020
medline: 17 9 2020
Statut: ppublish

Résumé

This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group. Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012. Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean  (SE) of 1.2  (0.2) kg and 1.8  (0.2) kg, respectively (P = 0.003). In addition, 31% of ILI and 23.9% of DSE participants gained ≥ 2% (P < 0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost ≥ 2% of EOI weight (P = 0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants. Both groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained ≥ 2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.

Identifiants

pubmed: 32320144
doi: 10.1002/oby.22769
pmc: PMC7437140
mid: NIHMS1559330
doi:

Types de publication

Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

893-901

Subventions

Organisme : NIDDK NIH HHS
ID : DK57177
Pays : United States
Organisme : NHLBI NIH HHS
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057219
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057154
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57219
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057182
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057136
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057002
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57149
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057131
Pays : United States
Organisme : NINR NIH HHS
ID : K23NR017209
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056336
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057008
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057149
Pays : United States
Organisme : NINR NIH HHS
ID : K23 NR017209
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57131
Pays : United States
Organisme : NIMHD NIH HHS
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057151
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57182
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57171
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057135
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57136
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57151
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK056992
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057171
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57008
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57135
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57178
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK56990
Pays : United States
Organisme : Indian Health Service
Pays : International
Organisme : NIDDK NIH HHS
ID : P30 DK111022
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057177
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57078
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK072488
Pays : United States
Organisme : Office of Research on Women's Health
Pays : International
Organisme : NIDDK NIH HHS
ID : U01 DK057078
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57154
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK056990
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057178
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57002
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK56992
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : CDC HHS
Pays : United States

Informations de copyright

© 2020 The Obesity Society.

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Auteurs

Ariana M Chao (AM)

Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Thomas A Wadden (TA)

Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Robert I Berkowitz (RI)

Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

George Blackburn (G)

Division of Nutrition, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Paula Bolin (P)

Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.

Jeanne M Clark (JM)

Division of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Mace Coday (M)

Departments of Preventive Medicine and Psychiatry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Jeffrey M Curtis (JM)

Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.

Linda M Delahanty (LM)

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Gareth R Dutton (GR)

Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Mary Evans (M)

Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

Linda J Ewing (LJ)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

John P Foreyt (JP)

Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Linda J Gay (LJ)

Department of Psychiatry, The Miriam Hospital, Brown Medical School, Providence, Rhode Island, USA.

Edward W Gregg (EW)

Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Helen P Hazuda (HP)

Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

James O Hill (JO)

Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Edward S Horton (ES)

Department of Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, Massachusetts, USA.

Denise K Houston (DK)

Department of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA.

John M Jakicic (JM)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Robert W Jeffery (RW)

Divisions of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.

Karen C Johnson (KC)

Departments of Preventive Medicine and Psychiatry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Steven E Kahn (SE)

Division of Metabolism, Endocrinology and Nutrition, US Department of Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.

William C Knowler (WC)

Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.

Anne Kure (A)

Division of Metabolism, Endocrinology and Nutrition, US Department of Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.

Katherine L Michalski (KL)

Division of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Maria G Montez (MG)

Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

Rebecca H Neiberg (RH)

Department of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA.

Jennifer Patricio (J)

Department of Medicine, St. Luke's Roosevelt Hospital Center, Columbia University, New York, New York, USA.

Anne Peters (A)

Division of Endocrinology, University of Southern California, Los Angeles, California, USA.

Xavier Pi-Sunyer (X)

Department of Medicine, St. Luke's Roosevelt Hospital Center, Columbia University, New York, New York, USA.

Henry Pownall (H)

Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

David Reboussin (D)

Department of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA.

Bruce Redmon (B)

Divisions of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.

W Jack Rejeski (WJ)

Department of Internal Medicine - Geriatrics, Wake Forest University, Winston-Salem, North Carolina, USA.

Helmut Steinburg (H)

Departments of Preventive Medicine and Psychiatry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Martha Walker (M)

Division of Endocrinology, University of Southern California, Los Angeles, California, USA.

Donald A Williamson (DA)

Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.

Rena R Wing (RR)

Department of Psychiatry, The Miriam Hospital, Brown Medical School, Providence, Rhode Island, USA.

Holly Wyatt (H)

Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Susan Z Yanovski (SZ)

Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

Ping Zhang (P)

Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

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