Size and Charge Adaptive Clustered Nanoparticles Targeting the Biofilm Microenvironment for Chronic Lung Infection Management.

Anti-Bacterial Agents / pharmacology Azithromycin / pharmacology Biofilms Lung Nanoparticles
antibiotic resistance azithromycin biofilm penetration nanoparticle permeability

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
26 05 2020
Historique:
pubmed: 23 4 2020
medline: 15 5 2021
entrez: 23 4 2020
Statut: ppublish

Résumé

Chronic lung infection caused by bacterial biofilms is an extremely serious clinical problem, which can lead to the failure of antibiotic therapy. Although nanoparticles have shown great potential in the treatment of biofilms, the efficient penetration and retention of nanoparticles in biofilms is still a big challenge. To address this issue, we herein fabricate size and charge adaptive azithromycin (AZM)-conjugated clustered nanoparticles (denoted as AZM-DA NPs) as therapeutic agents for treating biofilms. The AZM-DA NPs are prepared by electrostatic complexation between AZM conjugated amino-ended poly(amidoamine) dendrimer (PAMAM) and 2,3-dimethyl maleic anhydride (DA) modified poly(ethylene glycol)-

Identifiants

DOI: 10.1021/acsnano.0c00269 PMID: 32320228
pubmed: 32320228
doi: 10.1021/acsnano.0c00269
doi:

Substances chimiques

Anti-Bacterial Agents 0
Azithromycin 83905-01-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5686-5699

Auteurs

Yifan Gao (Y)

MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.

Jing Wang (J)

MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.

Mengying Chai (M)

MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.

Xu Li (X)

MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.

Yongyan Deng (Y)

MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.

Qiao Jin (Q)

MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
ORCID: 0000-0002-6584-4111

Jian Ji (J)

MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
ORCID: 0000-0001-9870-4038

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Size and Charge Adaptive Clustered...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Érythromycine › Azithromycine › Size and Charge Adaptive Clustered...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › Size and Charge Adaptive Clustered...
questionsmedicales.fr › Appareil respiratoire › Poumon › Size and Charge Adaptive Clustered...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Size and Charge Adaptive Clustered...