Immunology of carbohydrate-based vaccines.
Carbohydrate
Glycoconjugate
Glycolipid
Immune response
Oligosaccharides
Polysaccharides
Vaccines
Zwitterionic
Journal
Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
03
2020
revised:
13
04
2020
accepted:
17
04
2020
pubmed:
23
4
2020
medline:
21
9
2021
entrez:
23
4
2020
Statut:
ppublish
Résumé
Carbohydrates are considered as promising targets for vaccine development against infectious diseases where cell surface glycan's on many infectious agents are attributed to playing an important role in pathogenesis. Understanding the relationship between carbohydrates and immune components at a molecular level is crucial for the development of well-defined vaccines. Recently, carbohydrate immunology research has been accelerated by the development of new technologies that contribute to the design of optimum antigens, synthesis of antigens and the studies of antigen-antibody interactions, and as a result, several promising carbohydrate-based vaccine candidates have been prepared in recent years. This article briefly presents the mechanistic pathways of polysaccharide, glycoconjugate, glycolipid and zwitterionic vaccines and the interplay between carbohydrate antigen and immune response.
Identifiants
pubmed: 32320714
pii: S0169-409X(20)30026-0
doi: 10.1016/j.addr.2020.04.006
pii:
doi:
Substances chimiques
Antigens
0
Carbohydrates
0
Glycoconjugates
0
Glycolipids
0
Polysaccharides
0
Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-126Informations de copyright
Copyright © 2020. Published by Elsevier B.V.