Playing the piano with the cortex: role of neuronal ensembles and pattern completion in perception and behavior.
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
12
03
2020
revised:
27
03
2020
accepted:
28
03
2020
pubmed:
23
4
2020
medline:
28
1
2021
entrez:
23
4
2020
Statut:
ppublish
Résumé
Neuronal ensembles, i.e. coactive groups of neurons, have been long postulated to be functional building blocks of cortical circuits and units of the neural code. Calcium imaging of neuronal populations has demonstrated the widespread existence of spontaneous and sensory-evoked ensembles in cortical circuits in vivo. The development of two-photon optical techniques to simultaneously record and activate neurons with single cell resolution ("piano" experiments) has revealed the existence of pattern completion neurons, which can trigger an entire ensemble, and demonstrated a causal relation between ensembles and behavior. We review recent results controlling visual perception with targeted holographic manipulation of cortical ensembles by stimulating pattern completion neurons. Analyzing population activity as neuronal ensembles and exploiting pattern completion could enable control of brain states in health and disease.
Identifiants
pubmed: 32320944
pii: S0959-4388(20)30077-5
doi: 10.1016/j.conb.2020.03.014
pmc: PMC8006069
mid: NIHMS1681807
pii:
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-95Subventions
Organisme : NEI NIH HHS
ID : R01 EY011787
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115900
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110422
Pays : United States
Organisme : NINDS NIH HHS
ID : R34 NS116740
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
Brain Res. 2015 Jan 21;1595:51-73
pubmed: 25446438
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4053-61
pubmed: 25201983
Neuron. 2005 Dec 8;48(5):811-23
pubmed: 16337918
Nat Neurosci. 2014 Dec;17(12):1816-24
pubmed: 25402854
Nat Methods. 2018 Oct;15(10):805-815
pubmed: 30224673
Elife. 2018 Jun 05;7:
pubmed: 29869986
Neuron. 2012 Jun 21;74(6):970-4
pubmed: 22726828
BMC Biol. 2019 Sep 12;17(1):71
pubmed: 31514747
Int J Neural Syst. 2015 Nov;25(7):1550026
pubmed: 26173906
Nature. 2018 Nov;563(7729):72-78
pubmed: 30382198
Elife. 2018 Feb 07;7:
pubmed: 29412138
Cell. 2019 Jul 11;178(2):447-457.e5
pubmed: 31257030
Curr Biol. 2017 Apr 24;27(8):1085-1097
pubmed: 28366745
Cell Syst. 2019 May 22;8(5):467-474.e4
pubmed: 31054810
Nat Rev Neurosci. 2015 Aug;16(8):487-97
pubmed: 26152865
Nature. 2004 Feb 19;427(6976):704-10
pubmed: 14973477
Neuron. 2017 Apr 5;94(1):153-167.e8
pubmed: 28384469
Annu Rev Biophys. 2017 May 22;46:271-293
pubmed: 28301770
Science. 2019 Aug 9;365(6453):
pubmed: 31320556
Nat Biotechnol. 2016 Aug;34(8):857-62
pubmed: 27347754
Nature. 2011 May 5;473(7345):87-91
pubmed: 21478872
Cell Rep. 2017 Oct 10;21(2):381-392
pubmed: 29020625
Nature. 2019 Jan;565(7741):645-649
pubmed: 30651638
Neuron. 2015 Jun 17;86(6):1478-90
pubmed: 26051421
Philos Trans R Soc Lond B Biol Sci. 1971 Jul 1;262(841):23-81
pubmed: 4399412
Nat Methods. 2015 Feb;12(2):140-6
pubmed: 25532138
Science. 2016 Aug 12;353(6300):691-4
pubmed: 27516599
Neuron. 1991 Mar;6(3):333-44
pubmed: 1672071
Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8835-8840
pubmed: 30104363
Nat Methods. 2007 Nov;4(11):943-50
pubmed: 17965719
Nature. 1961 Dec 30;192:1227-32
pubmed: 13882203
Nature. 2020 Mar;579(7798):256-259
pubmed: 32132709
J Neurosci. 2019 Oct 23;39(43):8562-8575
pubmed: 31427393
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2554-8
pubmed: 6953413
Nature. 2003 May 15;423(6937):283-8
pubmed: 12748641
J Neurosci. 2015 Jun 10;35(23):8813-28
pubmed: 26063915
Nat Methods. 2017 Apr;14(4):349-359
pubmed: 28362436
Nature. 2019 Mar;567(7748):334-340
pubmed: 30842660
Nature. 1998 Mar 26;392(6674):387-90
pubmed: 9537321
Science. 1986 Aug 8;233(4764):625-33
pubmed: 3755256
Nature. 1995 Jun 22;375(6533):682-4
pubmed: 7791901
Nat Methods. 2012 Dec;9(12):1202-5
pubmed: 23142873