Runx1t1 promotes the neuronal differentiation in rat hippocampus.

Animals Cell Differentiation Hippocampus Neural Stem Cells Neurogenesis Neurons Rats
Differentiation Hippocampus Neural stem cells Neurogenesis Neuron Runx1t1

Journal

Stem cell research & therapy
ISSN: 1757-6512
Titre abrégé: Stem Cell Res Ther
Pays: England
ID NLM: 101527581

Informations de publication

Date de publication:
22 04 2020
Historique:
received: 06 01 2020
accepted: 31 03 2020
revised: 20 03 2020
entrez: 24 4 2020
pubmed: 24 4 2020
medline: 22 6 2021
Statut: epublish

Résumé

Runt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of radial glia cells in vitro. To better uncover the role of Runx1t1 in hippocampal neurogenesis, in this study, we further explore its localization and function during the hippocampal neurogenesis. Our results showed that insufficient expression of Runx1t1 reduced the neuronal differentiation, and overexpression of Runx1t1 promoted the neuronal differentiation in vitro. We also found that Runx1t1 localized in neurons but not astrocytes both in vivo and in vitro. Furthermore, we found that Runx1t1 overexpression elevated the number of newborn neurons in the hippocampal dentate gyrus. Taken together, our results further proved that Runx1t1 could be worked as a regulator in the process of hippocampal neurogenesis.

Sections du résumé

BACKGROUND
Runt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of radial glia cells in vitro.
METHODS
To better uncover the role of Runx1t1 in hippocampal neurogenesis, in this study, we further explore its localization and function during the hippocampal neurogenesis.
RESULTS
Our results showed that insufficient expression of Runx1t1 reduced the neuronal differentiation, and overexpression of Runx1t1 promoted the neuronal differentiation in vitro. We also found that Runx1t1 localized in neurons but not astrocytes both in vivo and in vitro. Furthermore, we found that Runx1t1 overexpression elevated the number of newborn neurons in the hippocampal dentate gyrus.
CONCLUSIONS
Taken together, our results further proved that Runx1t1 could be worked as a regulator in the process of hippocampal neurogenesis.

Identifiants

DOI: 10.1186/s13287-020-01667-x PMID: 32321587 PMC: PMC7178948
pubmed: 32321587
doi: 10.1186/s13287-020-01667-x
pii: 10.1186/s13287-020-01667-x
pmc: PMC7178948
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

160

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Auteurs

Linqing Zou (L)

Department of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China.
Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

Haoming Li (H)

Department of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China.
Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.

Xiao Han (X)

Department of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China.

Jianbing Qin (J)

Department of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China.

Guoqi Song (G)

Department of Hematology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China. sdsonggq@163.com.
Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA. sdsonggq@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Runx1t1 promotes the neuronal differentiation...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Runx1t1 promotes the neuronal differentiation...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Runx1t1 promotes the neuronal differentiation...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches neurales › Runx1t1 promotes the neuronal differentiation...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › Runx1t1 promotes the neuronal differentiation...
questionsmedicales.fr › Cellules › Neurones › Runx1t1 promotes the neuronal differentiation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Runx1t1 promotes the neuronal differentiation...