A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells.

Carcinoma, Hepatocellular / metabolism Cell Line, Tumor Humans Liver Neoplasms / metabolism Neoplasm Proteins / metabolism Proteomics Receptors, Lysophosphatidic Acid / metabolism
Biomarkers Hepatocellular carcinoma Lysophosphatidic acid receptor 6 (LPAR6) Mass spectrometry Protein signature Proteomics

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
11 06 2020
Historique:
received: 14 03 2020
accepted: 10 04 2020
pubmed: 24 4 2020
medline: 26 11 2020
entrez: 24 4 2020
Statut: ppublish

Résumé

Hepatocellular carcinoma (HCC) is the most commonly diagnosed liver malignancy, ranking third in the overall global cancer-related mortality. A complex network of interacting proteins controls HCC growth and progression. Lysophosphatidic acid receptors (LPAR) are commonly overexpressed in HCC. In particular, we have previously reported that the expression of LPAR6 sustains tumorigenesis and growth of HCC and results in a poor prognosis in HCC patients. Here, we applied a comparative proteomic approach to compare protein expression in both LPAR6 expressing (HLE-LPAR6) and nonexpressing HCC cells (HLE-neo). We found changes in the expression levels of 19 proteins, which include carbohydrate metabolism enzymes, redox and detoxification enzymes, and gene-expression regulatory proteins. Our findings support the role of LPAR6 in controlling the expression of a distinctive protein signature in HCC cells, which can offer a valuable resource for the identification of potential theranostic biomarkers.

Identifiants

DOI: 10.1016/j.bbrc.2020.04.036 PMID: 32321639
pubmed: 32321639
pii: S0006-291X(20)30762-2
doi: 10.1016/j.bbrc.2020.04.036
pii:
doi:

Substances chimiques

LPAR6 protein, human 0
Neoplasm Proteins 0
Receptors, Lysophosphatidic Acid 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1150-1156

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declared that they have no competing interests.

Auteurs

Rosa Lippolis (R)

Institute of Biomembranes and Bioenergetics, National Research Council, Bari, Italy.

Davide Gnocchi (D)

Interdisciplinary Department of Medicine, University of Bari School of Medicine, Piazza G. Cesare, 11, 70124, Bari, Italy.

Luigi Santacroce (L)

Ionian Department (DJSGEM), Microbiology and Virology Lab., University Hospital of Bari, 70124, Bari, Italy.

Rosa Anna Siciliano (RA)

Institute of Food Sciences, National Research Council (CNR-ISA), Avellino, Italy.

Maria Fiorella Mazzeo (MF)

Institute of Food Sciences, National Research Council (CNR-ISA), Avellino, Italy.

Salvatore Scacco (S)

Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", Bari, Italy.

Carlo Sabbà (C)

Interdisciplinary Department of Medicine, University of Bari School of Medicine, Piazza G. Cesare, 11, 70124, Bari, Italy.

Antonio Mazzocca (A)

Interdisciplinary Department of Medicine, University of Bari School of Medicine, Piazza G. Cesare, 11, 70124, Bari, Italy. Electronic address: antonio.mazzocca@uniba.it.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › A distinctive protein signature induced by...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › A distinctive protein signature induced by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A distinctive protein signature induced by...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › A distinctive protein signature induced by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › A distinctive protein signature induced by...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › A distinctive protein signature induced by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux lysophospholipides › Récepteurs à l'acide phosphatidique › A distinctive protein signature induced by...