Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication.
Animals
Cell Line
Chlorocebus aethiops
Humans
Kinetics
Nucleocapsid Proteins
/ genetics
Phosphoproteins
/ genetics
Protein Binding
RNA, Messenger
/ metabolism
RNA, Viral
/ genetics
RNA-Dependent RNA Polymerase
/ genetics
Ribonucleoproteins
/ metabolism
Transcription, Genetic
/ genetics
Vero Cells
Vesicular Stomatitis
/ virology
Vesiculovirus
/ genetics
Viral Proteins
/ genetics
Virus Replication
/ genetics
genome replication
oligomerization
phosphoprotein
polymerase
vesicular stomatitis virus
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
16 06 2020
16 06 2020
Historique:
received:
22
01
2020
accepted:
15
04
2020
pubmed:
24
4
2020
medline:
18
12
2020
entrez:
24
4
2020
Statut:
epublish
Résumé
Nonsegmented negative-strand (NNS) RNA viruses possess a ribonucleoprotein template in which the genomic RNA is sequestered within a homopolymer of nucleocapsid protein (N). The viral RNA-dependent RNA polymerase (RdRP) resides within an approximately 250-kDa large protein (L), along with unconventional mRNA capping enzymes: a GDP:polyribonucleotidyltransferase (PRNT) and a dual-specificity mRNA cap methylase (MT). To gain access to the N-RNA template and orchestrate the L
Identifiants
pubmed: 32321813
pii: JVI.00115-20
doi: 10.1128/JVI.00115-20
pmc: PMC7307139
pii:
doi:
Substances chimiques
Nucleocapsid Proteins
0
Phosphoproteins
0
RNA, Messenger
0
RNA, Viral
0
Ribonucleoproteins
0
Viral Proteins
0
L protein, vesicular stomatitis virus
EC 2.7.7.48
RNA-Dependent RNA Polymerase
EC 2.7.7.48
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI059371
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI059371
Pays : United States
Informations de copyright
Copyright © 2020 Bloyet et al.
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