B Cell-Intrinsic Expression of Interferon Regulatory Factor 1 Supports Chronic Murine Gammaherpesvirus 68 Infection.

Animals B-Lymphocytes / immunology Female Gammaherpesvirinae / genetics Germinal Center / immunology Herpesviridae Infections / genetics Host-Pathogen Interactions Interferon Regulatory Factor-1 / genetics Lymphocyte Activation Male Mice Mice, Inbred C57BL Spleen / virology Virus Latency / genetics
IRF-1 chronic infection gammaherpesvirus germinal center B cell

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
16 06 2020
Historique:
received: 05 03 2020
accepted: 10 04 2020
pubmed: 24 4 2020
medline: 18 12 2020
entrez: 24 4 2020
Statut: epublish

Résumé

Gammaherpesviruses are ubiquitous pathogens that are associated with cancers, including B cell lymphomas. These viruses are unique in that they infect naive B cells and subsequently drive a robust polyclonal germinal center response in order to amplify the latent reservoir and to establish lifelong infection in memory B cells. The gammaherpesvirus-driven germinal center response in combination with robust infection of germinal center B cells is thought to precipitate lymphomagenesis. Importantly, host and viral factors that selectively affect the gammaherpesvirus-driven germinal center response remain poorly understood. Global deficiency of antiviral tumor-suppressive

Identifiants

DOI: 10.1128/JVI.00399-20 PMID: 32321819 PMC: PMC7307145
pubmed: 32321819
pii: JVI.00399-20
doi: 10.1128/JVI.00399-20
pmc: PMC7307145
pii:
doi:

Substances chimiques

Interferon Regulatory Factor-1 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : F31 CA243364
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA183593
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA203923
Pays : United States

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

C N Jondle (CN)

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

K E Johnson (KE)

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

A A Uitenbroek (AA)

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

P A Sylvester (PA)

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

C Nguyen (C)

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

W Cui (W)

Versiti Blood Research Institute, Milwaukee, Wisconsin, USA.

V L Tarakanova (VL)

Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA vera@mcw.edu.
Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Gammaherpesvirinae › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Centre germinatif › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ADN › Infections à Herpesviridae › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Facteur-1 de régulation d'interféron › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › B Cell-Intrinsic Expression of Interferon...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Latence virale › B Cell-Intrinsic Expression of Interferon...