The clinical phenotype associated with antisynthetase autoantibodies.
antisynthetase antibodies
antisynthetase syndrome
idiopathic inflammatory myopathy
Journal
Reumatologia
ISSN: 0034-6233
Titre abrégé: Reumatologia
Pays: Poland
ID NLM: 20130190R
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
01
2020
accepted:
10
02
2020
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
24
4
2020
Statut:
ppublish
Résumé
Specific systemic autoimmune syndrome characterized by inflammatory myopathy, arthritis or arthralgias, interstitial lung disease (ILD), fever, Raynaud's phenomenon, and mechanic's hands is called antisynthetase syndrome (AS). The aim of this study was to assess the clinical spectrum associated with presence of aminoacyl-transfer RNA synthetase autoantibodies (ASA). A total of 305 patients with presence of myositis-specific autoantibodies were identified in the database of immunological tests performed in the Clinical Immunology and Transplantology Unit, Medical University of Gdansk between January 2011 and March 2016. In 110 patients (36%) ASA were detected. The detailed analysis included 50 patients with ASA for whom full clinical data were available. The incidence of specific ASA in the analyzed group was: Jo-1 46% (23 patients), PL-12 32% (16 patients), PL-7 16% (8 patients), OJ 12% (6 patients), EJ 6% (3 patients). In 10% (5 patients) there was coexistence of at least one ASA, and in another 5 patients there was coexistence of ASA with other antibodies specific for myositis (MSA). In the analyzed group of patients 11 (22%) satisfied the Bohan and Peter criteria for dermatomyositis, 1 for polymyositis. In 5 patients (10%) based on clinical presentation and ASA presence the AS was recognized. Another 3 patients met the criteria of the overlap syndrome polymyositis respectively with systemic lupus, rheumatoid arthritis, and scleroderma. In 5 patients undifferentiated connective tissue disease was diagnosed, and 14 consecutive patients were diagnosed with other connective tissue diseases, while 12 patients did not receive a definitive diagnosis. The clinical presentation of patients with the presence of ASA is varied. Their presence indicates not only idiopathic inflammatory myopathies, but also non-specifically other disease entities. These patients require observation for the development of idiopathic inflammatory myopathy, and ILD.
Identifiants
pubmed: 32322117
doi: 10.5114/reum.2020.93505
pii: 93505
pmc: PMC7174798
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4-8Informations de copyright
Copyright: © 2020 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Clinics (Sao Paulo). 2013 Jul;68(7):909-14
pubmed: 23917652
Curr Rheumatol Rep. 2018 Mar 17;20(4):18
pubmed: 29550929
Medicine (Baltimore). 2013 Jan;92(1):15-24
pubmed: 23269233
Ann Rheum Dis. 2014 Jan;73(1):227-32
pubmed: 23422076
Autoimmun Rev. 2012 Dec;12(2):210-7
pubmed: 22771754
Autoimmun Rev. 2014 Sep;13(9):883-91
pubmed: 24704867
Rheumatology (Oxford). 2007 May;46(5):842-5
pubmed: 17255133
Autoimmunity. 2006 May;39(3):233-41
pubmed: 16769657
JAMA Neurol. 2018 Dec 1;75(12):1528-1537
pubmed: 30208379
N Engl J Med. 1975 Feb 20;292(8):403-7
pubmed: 1089199
PLoS One. 2013;8(4):e60442
pubmed: 23573256
Chest. 2009 Jun;135(6):1550-1556
pubmed: 19225060
Arthritis Rheumatol. 2017 Dec;69(12):2271-2282
pubmed: 29106061
Auto Immun Highlights. 2014 Aug 23;5(3):69-75
pubmed: 26000158
Arthritis Rheum. 2007 Apr;56(4):1295-303
pubmed: 17393393
J Rheumatol. 2007 May;34(5):1012-8
pubmed: 17309126
Rheum Dis Clin North Am. 2002 Nov;28(4):859-90, viii
pubmed: 12506776
JAMA Neurol. 2017 Aug 1;74(8):992-999
pubmed: 28586844
N Engl J Med. 1975 Feb 13;292(7):344-7
pubmed: 1090839
PLoS One. 2015 Mar 19;10(3):e0120313
pubmed: 25789468
Curr Rheumatol Rep. 2011 Jun;13(3):175-81
pubmed: 21455765