Genotoxicity of micro- and nano-particles of kaolin in human primary dermal keratinocytes and fibroblasts.
Genotoxicity
Kaolin
Nanoparticle
Primary human keratinocyte
Journal
Genes and environment : the official journal of the Japanese Environmental Mutagen Society
ISSN: 1880-7046
Titre abrégé: Genes Environ
Pays: England
ID NLM: 101285347
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
01
2020
accepted:
02
04
2020
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
24
4
2020
Statut:
epublish
Résumé
Kaolin is a clay mineral with the chemical composition Al After 6-h treatment with kaolin micro- and nano-particles of particle sizes 4.8 μm and 0.2 μm (200 nm), respectively, the frequencies of micronucleated cells increased in a dose-dependent manner. The frequency increased 3- to 4-fold by exposure to the particles at 200 μg/mL (i.e. Kaolin particles demonstrated genotoxicity in primary normal human diploid epidermal keratinocytes and fibroblasts as well as in CHO AA8 cells. Although no significant difference was observed among these three types of cells, fine particles of kaolin tended to have higher genotoxic potency than coarse particles. Since studies on its genotoxicity to skin have been scarce, the findings of the present study could contribute to safety evaluations of kaolin particles when used as a white cosmetic pigment.
Identifiants
pubmed: 32322315
doi: 10.1186/s41021-020-00155-1
pii: 155
pmc: PMC7164293
doi:
Types de publication
Journal Article
Langues
eng
Pagination
16Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe author declares that he has no competing interests.
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