Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient.
Biopsy
Diffuse astrocytoma
Follow-up MRI
Neurofibromatosis
Spinal cord
Journal
Radiology case reports
ISSN: 1930-0433
Titre abrégé: Radiol Case Rep
Pays: Netherlands
ID NLM: 101467888
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
25
01
2020
revised:
25
02
2020
accepted:
26
02
2020
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
24
4
2020
Statut:
epublish
Résumé
Neurofibromatosis type 1 (NF1) is one of the most common genetic neurocutaneous disorders, and it is well known to be associated with peripheral or central nervous system malignancies. The most common malignant tumors are malignant peripheral nerve sheath tumors (MPNSTs); MPNSTs are the most common cause of death in patients with NF1. Central nervous system malignancies rarely occur. So far, the occurrence of spinal cord malignancies is exceedingly rare. Herein, we report a rare case of a 69-year-old male with NF1 following tumor resection twice for cutaneous MPNSTs developing intramedullary diffuse astrocytoma in the conus medullaris, which initially presented with traumatic spinal cord injury associated with a compression fracture from fall. Contrast-enhanced magnetic resonance imaging and biopsy of the spinal cord were required to establish the final diagnosis.
Identifiants
pubmed: 32322332
doi: 10.1016/j.radcr.2020.02.033
pii: S1930-0433(20)30074-1
pmc: PMC7167499
doi:
Types de publication
Case Reports
Langues
eng
Pagination
784-788Informations de copyright
© 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.
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