Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patients.
Breast cancer
Ion torrent sequencing
Next Generation Sequencing
Somatic mutations
Target sequencing
Journal
Journal of advanced research
ISSN: 2090-1232
Titre abrégé: J Adv Res
Pays: Egypt
ID NLM: 101546952
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
19
12
2019
revised:
17
02
2020
accepted:
01
04
2020
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
24
4
2020
Statut:
epublish
Résumé
Breast cancer (BC) incidence is progressively increasing in Egypt. However, there is insufficient knowledge of the acquired somatic mutations in Egyptian BC patients which limit our understanding of its progression. To the best of our knowledge, this is the first Egyptian cohort to sequence a multiple-gene panel of cancer related genes on BC patients. Four hundred and nine cancer related genes were sequenced in 46 fresh breast tumors of Egyptian BC patients to identify somatic mutations and their frequencies.
Identifiants
pubmed: 32322420
doi: 10.1016/j.jare.2020.04.001
pii: S2090-1232(20)30063-1
pmc: PMC7167517
doi:
Types de publication
Journal Article
Langues
eng
Pagination
149-157Informations de copyright
© 2020 THE AUTHORS. Published by Elsevier BV on behalf of Cairo University.
Déclaration de conflit d'intérêts
The authors declared that there is no conflict of interest.
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