Intracranial Mesenchymal Chondrosarcoma Lacking the Typical Histopathological Features Diagnosed by
HEY1-NCOA2
IRF2BP2-CDX1
gene fusion
mesenchymal chondrosarcoma
Journal
NMC case report journal
ISSN: 2188-4226
Titre abrégé: NMC Case Rep J
Pays: Japan
ID NLM: 101692589
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
13
06
2019
accepted:
13
08
2019
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
24
4
2020
Statut:
epublish
Résumé
Intracranial mesenchymal chondrosarcoma (MCS) is a rare neoplasm. The diagnosis of MCS is confirmed by the presence of a biphasic pattern on histological examination, comprising undifferentiated small round cells admixed with islands of well-differentiated hyaline cartilage; however, a differential diagnosis may be challenging in some cases. A 28-year-old woman with a 2-month history of headache was referred to our hospital. Radiologic studies showed an extra-axial lobulated mass composed of calcified and uncalcified areas occupying the left middle fossa. Surgical resection was planned, but her headache suddenly worsened before her planned hospital admission and she was admitted as an emergency. Radiologic studies showed an acute hemorrhage in the uncalcified part of the mass. The mass was resected via the left zygomatic approach after embolization of the feeder vessels. The most likely histopathological diagnosis was MCS. However, the typical bimorphic pattern was not identified in our surgical samples; each undifferentiated area and well-differentiated area was observed separately in different tissue specimens, and no islands of well-differentiated hyaline cartilage were identified within the undifferentiated areas in the same specimen. Molecular assays confirmed the presence of
Identifiants
pubmed: 32322450
doi: 10.2176/nmccrj.cr.2019-0123
pii: nmccrj-7-47
pmc: PMC7162808
doi:
Types de publication
Case Reports
Langues
eng
Pagination
47-52Informations de copyright
© 2020 The Japan Neurosurgical Society.
Déclaration de conflit d'intérêts
Conflicts of Interest Disclosure The authors declare that they have no conflicts of interest.
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