Targeting autophagy-related protein kinases for potential therapeutic purpose.
4E-BP1, eukaryotic translation initiation factor 4E-binding protein
AKT1, AKT serine/threonine kinase 1
AMBRA1, autophagy/beclin-1 regulator 1
AMPK, AMP-activated protein kinase
ARF, auxin response factor gene
ATG, autophagy-related protein
Autophagy
Autophagy-related kinase
CaMKK2, calcium/calmodulin-dependent protein kinase kinase 2
DAPK, death associated protein kinase
FIP200, FAK family kinase-interacting protein of 200 kDa
GAP, GTPase-activating protein
GO, gene ontology
GSK3α, glycogen synthase kinase 3 alpha
HMGB1, high mobility group protein B1
Human disease therapy
JNK1, C-Jun N-terminal kinase
LC3, microtubule-associated protein 1 light chain 3
LKB1, serine/threonine-protein kinase stk11
LPS, lipopolysaccharide
LRRK2, leucine rich repeat kinase 2
PD, Parkinson's disease
PI, phosphatidylinositol
PI3 kinase, phosphoinositide 3-kinase
PI3P, phosphatidylinositol triphosphate
PIM2, proviral insertion in murine lymphomas 2
PINK1, PTEN-induced putative kinase 1
PIP2, phosphatidylinositol-4,5-bisphosphate
PKACα, a protein kinase cAMP-activated catalytic subunit alpha
PKCα, protein kinase C alpha type
PKD1, polycystin-1
PPIs, protein–protein interactions
PROTAC, proteolysis targeting chimeras
PTMs, post-translational modifications
Phosphorylation
Protein kinases
Rheb, the RAS homolog enriched in brain
Small-molecule kinase inhibitors/activators
TAK1, transforming growth factor activated kinase-1
TFEB, transcription factor EB
TNBC, triple-negative breast cancer
TSC1/2, tuberous sclerosis complex proteins 1/2
ULK complex, ULK1–mATG13–FIP200–ATG101 complex
ULK1, unc-51-like kinase 1
UVRAG, ultraviolet resistance-associated gene
mTOR, mammalian target of rapamycin
mTORC1, mammalian target of rapamycin complex 1
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
07
07
2019
revised:
06
08
2019
accepted:
09
09
2019
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
24
4
2020
Statut:
ppublish
Résumé
Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays a significant role in the quality control of macromolecules and organelles. Since protein kinases are integral to the autophagy process, it is critically important to understand the role of kinases in autophagic regulation. At present, intervention of autophagic processes by small-molecule modulators targeting specific kinases has becoming a reasonable and prevalent strategy for treating several varieties of human disease, especially cancer. In this review, we describe the role of some autophagy-related kinase targets and kinase-mediated phosphorylation mechanisms in autophagy regulation. We also summarize the small-molecule kinase inhibitors/activators of these targets, highlighting the opportunities of these new therapeutic agents.
Identifiants
pubmed: 32322463
doi: 10.1016/j.apsb.2019.10.003
pii: S2211-3835(19)30276-X
pmc: PMC7161711
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
569-581Informations de copyright
© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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