Development and Validation of a
Adult
Antigens, Bacterial
/ chemistry
Bordetella pertussis
/ genetics
Cytokines
/ metabolism
Enzyme-Linked Immunospot Assay
Epitopes, T-Lymphocyte
/ chemistry
Female
Genome-Wide Association Study
Humans
Immunologic Memory
Male
Pertussis Vaccine
/ administration & dosage
T-Lymphocytes
/ immunology
Vaccines, Acellular
/ administration & dosage
Vaccines, Inactivated
/ administration & dosage
Vaccines, Subunit
/ chemistry
Whooping Cough
/ immunology
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
01
2020
accepted:
06
03
2020
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
3
2
2021
Statut:
epublish
Résumé
The immune response elicited by the protective whole-cell pertussis (wP) versus the less-protective acellular pertussis (aP) vaccine has been well characterized; however, important clinical problems remain unsolved, as the inability of the currently administered aP vaccine is resulting in the reemergence of clinical disease (i.e., whooping cough). Strong evidence has shown that original, childhood aP and wP priming vaccines provide a long-lasting imprint on the CD4+ T cells that impacts protective immunity. However, aP vaccination might prevent disease but not infection, which might also affect the breadth of responses to
Identifiants
pubmed: 32322598
doi: 10.1155/2020/8202067
pmc: PMC7154976
doi:
Substances chimiques
Antigens, Bacterial
0
Cytokines
0
Epitopes, T-Lymphocyte
0
Pertussis Vaccine
0
Vaccines, Acellular
0
Vaccines, Inactivated
0
Vaccines, Subunit
0
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
8202067Subventions
Organisme : NIAID NIH HHS
ID : U01 AI141995
Pays : United States
Informations de copyright
Copyright © 2020 Ricardo da Silva Antunes et al.
Déclaration de conflit d'intérêts
The authors have declared that no conflict of interest exists.
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