Association of plasma levels of lipid and polychlorinated biphenyls in Iranian adult.
Biological sciences
Body mass index
Endocrinology
HDL
Health sciences
LDL
Polychlorinated biphenyls
Public health
Serum lipid
Triglyceride
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
14
06
2019
revised:
06
12
2019
accepted:
08
04
2020
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
24
4
2020
Statut:
epublish
Résumé
Exposure to Polychlorinated biphenyls (PCBs) continues over the world through seafood consumption and indoor exposure to building materials containing PCB. This study aimed to assess the relationship between plasma level of PCB congeners and lipid profile and Body Mass Index (BMI) as well. The study population consisted of 181 Iranian adults. Data on BMI, plasma concentration of PCB congeners and serum level of lipid profile including Triglyceride, low-density lipoproteins and high-density lipoproteins, recruited from database of a project entitled "Occupational and environmental exposure to PCBs in Iran". Multiple linear regression analysis of associations between different quartiles of PCB congeners and various lipid fractions and BMI have been conducted. A linear increase in average serum Triglyceride and low-density lipoproteins (LDL) levels of participants in first, second, third and fourth quartiles of some PCB congeners was obtained. Following adjustment for age, gender, diet and other variables, only the association between different quartiles of PCB 138, PCB 153, PCB 118 and PCB sum and TG remained statistically significant. The study showed a significant positive relation between plasma PCBs concentrations and serum level of TG in the study population with normal PCBs levels.
Sections du résumé
BACKGROUND
BACKGROUND
Exposure to Polychlorinated biphenyls (PCBs) continues over the world through seafood consumption and indoor exposure to building materials containing PCB. This study aimed to assess the relationship between plasma level of PCB congeners and lipid profile and Body Mass Index (BMI) as well.
METHODS
METHODS
The study population consisted of 181 Iranian adults. Data on BMI, plasma concentration of PCB congeners and serum level of lipid profile including Triglyceride, low-density lipoproteins and high-density lipoproteins, recruited from database of a project entitled "Occupational and environmental exposure to PCBs in Iran". Multiple linear regression analysis of associations between different quartiles of PCB congeners and various lipid fractions and BMI have been conducted.
RESULTS
RESULTS
A linear increase in average serum Triglyceride and low-density lipoproteins (LDL) levels of participants in first, second, third and fourth quartiles of some PCB congeners was obtained. Following adjustment for age, gender, diet and other variables, only the association between different quartiles of PCB 138, PCB 153, PCB 118 and PCB sum and TG remained statistically significant.
CONCLUSION
CONCLUSIONS
The study showed a significant positive relation between plasma PCBs concentrations and serum level of TG in the study population with normal PCBs levels.
Identifiants
pubmed: 32322735
doi: 10.1016/j.heliyon.2020.e03775
pii: S2405-8440(20)30620-4
pii: e03775
pmc: PMC7160561
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e03775Informations de copyright
© 2020 Published by Elsevier Ltd.
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