Effect of vaccination with a novel GnRH-based immunocontraceptive on immune responses and fertility in rats.
Fertility control
Human-wildlife conflicts
Immune response
Immunocontraception
Immunology
Oral contraceptive vaccine
Vaccination
Wildlife management
anti-GnRH vaccine
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
15
07
2019
revised:
26
09
2019
accepted:
09
04
2020
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
24
4
2020
Statut:
epublish
Résumé
1. As human-wildlife conflicts increase worldwide, novel methods are required for mitigating these conflicts. Fertility control, based on immunocontraceptives, has emerged as an alternative option to lethal methods for managing wildlife. 2. Immunocontraceptives are vaccines that generate an immune response to key components of an animal's reproductive system. Some of these vaccines target the gonadotropin-releasing hormone (GnRH) and have been used successfully as contraceptives for many wildlife species. However, the need to capture animals for treatment limits the field applications of injectable vaccines. The availability of orally delivered immunocontraceptives would increase the breadth of applications of fertility control for wildlife management. 3. This study explored a new approach to developing an oral immunocontraceptive, exploiting the bioadhesive and immunologically active properties of killed
Identifiants
pubmed: 32322739
doi: 10.1016/j.heliyon.2020.e03781
pii: S2405-8440(20)30626-5
pii: e03781
pmc: PMC7170952
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e03781Informations de copyright
© 2020 Published by Elsevier Ltd.
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