The role of serum Dickkopf-1 in predicting 30-day death in severe traumatic brain injury.
Dickkopf-1
humans
mortality
risk factors
severity
traumatic brain injury
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
07
11
2019
revised:
06
02
2020
accepted:
17
02
2020
pubmed:
24
4
2020
medline:
25
6
2021
entrez:
24
4
2020
Statut:
ppublish
Résumé
Dickkopf-1 (DKK-1), an inhibitor of the canonical/-catenin cascade of the Wnt pathway, was upregulated in brain tissues of hemorrhagic stroke rats, and its rising circulating levels were associated with poor prognosis of acute ischemic stroke patients. We attempted to ascertain the relationship between serum DKK-1 levels and 30-day death after severe traumatic brain injury (sTBI). Serum DKK-1 levels were gauged in a total of 94 sTBI patients and 94 healthy controls. Trauma severity was assessed using Glasgow Coma Scale (GCS) and Rotterdam classification based on head computerized tomography scan. Prognostic variable was 30-day death. Compared with controls, serum DKK-1 levels were substantially elevated in patients (median value, 3.7 versus 1.0 ng/ml). Area under receiver operating characteristic curve was 0.802 (95% confidence interval (CI), 0.708-0.877) for predicting 30-day death. Adjusted logistic regression showed that serum DKK-1 levels above 3.7 ng/ml remained as an independent marker of 30-day death (odds ratio, 8.573; 95% CI, 1.386-53.020) and overall survival (hazard ratio, 7.322; 95% CI, 1.320-40.622). An intimate correlation existed between DKK-1 levels and GCS scores (r = -.649) in addition to Rotterdam classification (r = .664). High serum levels of DKK-1 are closely associated with increasing severity and rising short-term mortality of sTBI.
Identifiants
pubmed: 32324340
doi: 10.1002/brb3.1589
pmc: PMC7303377
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01589Informations de copyright
© 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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