Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
19 05 2020
19 05 2020
Historique:
pubmed:
24
4
2020
medline:
20
1
2021
entrez:
24
4
2020
Statut:
ppublish
Résumé
Human reticulocyte 15-lipoxygenase-1 (h15-LOX-1 or ALOX15) and platelet 12-lipoxygenase (h12-LOX or ALOX12) catalysis of docosahexaenoic acid (DHA) and the maresin precursor, 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-HpDHA), were investigated to determine their product profiles and relative rates in the biosynthesis of the key maresin intermediate, 13S,14S-epoxy-4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid (13S,14S-epoxy-DHA). Both enzymes converted DHA to 14S-HpDHA, with h12-LOX having a 39-fold greater
Identifiants
pubmed: 32324389
doi: 10.1021/acs.biochem.0c00233
pmc: PMC7729281
mid: NIHMS1650491
doi:
Substances chimiques
Recombinant Proteins
0
Docosahexaenoic Acids
25167-62-8
Arachidonate 12-Lipoxygenase
EC 1.13.11.31
ALOX12 protein, human
EC 1.13.11.31.
ALOX15 protein, human
EC 1.13.11.33
Arachidonate 15-Lipoxygenase
EC 1.13.11.33
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1832-1844Subventions
Organisme : NHLBI NIH HHS
ID : R00 HL136784
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131835
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL136784
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM105671
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114405
Pays : United States
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