Antitubercular Ilamycins from Marine-Derived

Antineoplastic Agents / chemistry Antitubercular Agents / chemistry Cell Line, Tumor Drug Design Humans Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis / drug effects Streptomyces / chemistry Structure-Activity Relationship

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
22 05 2020
Historique:
pubmed: 24 4 2020
medline: 30 7 2021
entrez: 24 4 2020
Statut: ppublish

Résumé

Tuberculosis (TB) ranks as the leading cause of death from a single infectious agent (ranking more lethal than HIV/AIDS) over the course of the past decade. More concerning is that reports of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) strains of TB have been dramatically increasing. It continues to become ever more clear that novel anti-TB drugs with improved efficacies and reduced toxicities are urgently needed. We report here the discovery of 12 new ilamycin analogues, ilamycins G-R (

Identifiants

DOI: 10.1021/acs.jnatprod.0c00151 PMID: 32324401
pubmed: 32324401
doi: 10.1021/acs.jnatprod.0c00151
doi:

Substances chimiques

Antineoplastic Agents 0
Antitubercular Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1646-1657

Auteurs

Changli Sun (C)

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.

Zhiyong Liu (Z)

Tuberculosis Research Laboratory, State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Huangpu District, Guangzhou 510530, China.
Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou 510530, China.

Xiangcheng Zhu (X)

Xiangya International Academy of Translational Medicine, Central South University; National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, 172 Tongzipo Road, Changsha, Hunan 410013, China.
ORCID: 0000-0002-9191-6676

Zhiying Fan (Z)

Xiangya International Academy of Translational Medicine, Central South University; National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, 172 Tongzipo Road, Changsha, Hunan 410013, China.

Xuanmei Huang (X)

Guangdong Province Key Laboratory of Medical Molecular Diagnostics, Institute of Laboratory Medicine, Guangdong Medical University, 1 Xincheng Road, Dongguan 523808, China.

Qiaoling Wu (Q)

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
College of Oceanology, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 110039, China.

Xiaohong Zheng (X)

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.

Xiangjing Qin (X)

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
ORCID: 0000-0001-6708-1368

Tianyu Zhang (T)

Tuberculosis Research Laboratory, State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Huangpu District, Guangzhou 510530, China.
Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou 510530, China.
ORCID: 0000-0001-5647-6014

Hua Zhang (H)

Guangdong Province Key Laboratory of Medical Molecular Diagnostics, Institute of Laboratory Medicine, Guangdong Medical University, 1 Xincheng Road, Dongguan 523808, China.

Jianhua Ju (J)

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
College of Oceanology, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 110039, China.
ORCID: 0000-0001-7712-8027

Junying Ma (J)

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antitubercular Ilamycins from Marine-Derived
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Antitubercular Ilamycins from Marine-Derived
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Antitubercular Ilamycins from Marine-Derived
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Antitubercular Ilamycins from Marine-Derived
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antitubercular Ilamycins from Marine-Derived
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Antitubercular Ilamycins from Marine-Derived
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Antitubercular Ilamycins from Marine-Derived
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Antitubercular Ilamycins from Marine-Derived
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › Antitubercular Ilamycins from Marine-Derived
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Antitubercular Ilamycins from Marine-Derived