Constructing Adaptive Photosensitizers via Supramolecular Modification Based on Pillararene Host-Guest Interactions.
host-guest systems
molecular switches
photosensitizers
pillararenes
supramolecular chemistry
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
13 07 2020
13 07 2020
Historique:
received:
08
01
2020
revised:
14
04
2020
pubmed:
24
4
2020
medline:
26
3
2021
entrez:
24
4
2020
Statut:
ppublish
Résumé
In order to promote the development of photodynamic therapy (PDT), undesired side effects like low tumor specificity and the "always-on" phenomenon should be avoided. An effective solution is to construct an adaptive photosensitizer that can be activated to generate reactive oxygen species (ROS) in the tumor microenvironment. Herein, we design and synthesize a supramolecular switch based on a host-guest complex containing a water-soluble pillar[5]arene (WP5) and an AIEgen photosensitizer (G). The formation of the host-guest complex WP5⊃G quenches the fluorescence and inhibits ROS generation of G. Benefitting from the pH-responsiveness of WP5, the binding site between G and WP5 changes in an acidic environment through a shuttle movement. Consequently, fluorescence and ROS generation of the host-guest complex can be switched on at pH 5.0. This work offers a new paradigm for the construction of adaptive photosensitizers by using a supramolecular method.
Identifiants
pubmed: 32324962
doi: 10.1002/anie.202000338
doi:
Substances chimiques
Acids
0
Photosensitizing Agents
0
Reactive Oxygen Species
0
pillar(5)arene
0
Calixarenes
130036-26-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11779-11783Informations de copyright
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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