The Association of Multiparity with Lung Function and Chronic Obstructive Pulmonary Disease-Related Phenotypes.
chronic obstructive pulmonary disease
copd
female
hormones
multiparity
phenotypes
pregnancy
Journal
Chronic obstructive pulmonary diseases (Miami, Fla.)
ISSN: 2372-952X
Titre abrégé: Chronic Obstr Pulm Dis
Pays: United States
ID NLM: 101635411
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
24
4
2020
Statut:
ppublish
Résumé
Apparent increased female susceptibility to chronic obstructive pulmonary disease (COPD) suggests sex hormones modulate disease pathogenesis. Little is known about associations between multiparity and lung function in smokers. We hypothesized that multiparity is associated with lung function and measures of emphysema and airway disease. Utilizing female participants from the 5-year follow up of the COPD Genetic Epidemiology (COPDGene We included 1820 participants from COPDGene Multiparity was associated with lower FEV
Sections du résumé
BACKGROUND
BACKGROUND
Apparent increased female susceptibility to chronic obstructive pulmonary disease (COPD) suggests sex hormones modulate disease pathogenesis. Little is known about associations between multiparity and lung function in smokers.
RESEARCH QUESTION
OBJECTIVE
We hypothesized that multiparity is associated with lung function and measures of emphysema and airway disease.
STUDY DESIGN AND METHODS
METHODS
Utilizing female participants from the 5-year follow up of the COPD Genetic Epidemiology (COPDGene
RESULTS
RESULTS
We included 1820 participants from COPDGene
INTERPRETATION
CONCLUSIONS
Multiparity was associated with lower FEV
Identifiants
pubmed: 32324980
doi: 10.15326/jcopdf.7.2.2019.0166
pmc: PMC7454017
doi:
Types de publication
Journal Article
Langues
eng
Pagination
86-98Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL125858
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133135
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147148
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137927
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL132825
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL114501
Pays : United States
Organisme : COPD Foundation Industry Advisory Board
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089897
Pays : United States
Informations de copyright
JCOPDF © 2020.
Déclaration de conflit d'intérêts
MM is supported by National Institutes of Health grant T32HL007427. DLD is supported by P01 HL 114501 and P01 132825. EKS is supported by P01 HL114501, R01 HL133135, R01 HL137927, and R01 HL147148. JDC and EKS are supported by U01 HL089897 and U01 HL089856. SML is supported by National Heart, Lung and Blood Institute grant K01HL125858. EKS received grant and travel support from GlaxoSmithKline and grant support from Bayer. DLD has received grant support from Bayer.
Références
Blood. 2000 Jan 15;95(2):375-87
pubmed: 10627438
Br J Cancer. 2002 May 6;86(9):1425-9
pubmed: 11986775
J Womens Health (Larchmt). 2016 Jan;25(1):4-10
pubmed: 26771559
Lung Cancer. 2004 Sep;45(3):289-97
pubmed: 15301869
Am J Respir Crit Care Med. 2007 Jul 15;176(2):113-20
pubmed: 17413125
Am J Respir Crit Care Med. 2000 Dec;162(6):2152-8
pubmed: 11112130
Sci Transl Med. 2012 Jan 18;4(117):117ra9
pubmed: 22261033
Nat Rev Endocrinol. 2010 Jun;6(6):311-8
pubmed: 20421883
Ann Am Thorac Soc. 2015 Jul;12(7):988-96
pubmed: 25844673
Rev Mal Respir. 2003 Sep;20(4):521-30
pubmed: 14528154
Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1770-8
pubmed: 9620904
Stroke. 2001 Oct;32(10):2259-64
pubmed: 11588310
Chem Res Toxicol. 1992 Sep-Oct;5(5):639-46
pubmed: 1446003
Eur Respir Rev. 2017 Dec 6;26(146):
pubmed: 29212834
N Engl J Med. 1996 Sep 26;335(13):931-7
pubmed: 8782500
Am J Respir Crit Care Med. 2017 Apr 15;195(8):1058-1065
pubmed: 27907454
J Diabetes Investig. 2011 Aug 2;2(4):328-30
pubmed: 24843507
PLoS One. 2016 Jan 13;11(1):e0145753
pubmed: 26761206
Proc Am Thorac Soc. 2007 Dec;4(8):671-4
pubmed: 18073400
Radiology. 2011 Oct;261(1):274-82
pubmed: 21788524
Sci Rep. 2018 Jul 23;8(1):11100
pubmed: 30038336
Am J Respir Crit Care Med. 2007 Aug 1;176(3):243-52
pubmed: 17431226
Sci Rep. 2017 Mar 13;7:44232
pubmed: 28287180
Respir Res. 2006 Mar 29;7:52
pubmed: 16571126
Fertil Steril. 2012 Jan;97(1):118-24
pubmed: 22130321
MMWR Surveill Summ. 2002 Aug 2;51(6):1-16
pubmed: 12198919
Inflammation. 2016 Jun;39(3):1130-3
pubmed: 27090654
Respir Res. 2014 Aug 06;15:89
pubmed: 25096860
Expert Rev Clin Immunol. 2012 Mar;8(3):285-92
pubmed: 22390492
Pharmacol Ther. 2015 Jun;150:94-108
pubmed: 25595323
Immunol Res. 2014 Dec;60(2-3):184-92
pubmed: 25391611
Chimerism. 2011 Jul;2(3):84-5
pubmed: 22163066
Am J Respir Cell Mol Biol. 2005 May;32(5):367-72
pubmed: 15837726
Endocr Rev. 2007 Aug;28(5):521-74
pubmed: 17640948
Mater Sociomed. 2015 Aug;27(4):244-7
pubmed: 26543415
Am J Respir Crit Care Med. 1999 Jan;159(1):179-87
pubmed: 9872837
Clinics (Sao Paulo). 2017 Oct;72(10):595-599
pubmed: 29160421
Clin Mol Allergy. 2016 Sep 15;14:11
pubmed: 27651750
Front Immunol. 2018 Jan 25;9:66
pubmed: 29422903
Proc Am Thorac Soc. 2007 Dec;4(8):675-9
pubmed: 18073401
Front Neuroendocrinol. 2014 Aug;35(3):347-69
pubmed: 24793874
Am J Respir Crit Care Med. 2017 Mar 1;195(5):557-582
pubmed: 28128970
COPD. 2010 Feb;7(1):32-43
pubmed: 20214461
J Autoimmun. 2007 Aug;29(1):1-9
pubmed: 17582741
Autoimmun Rev. 2016 Apr;15(4):354-74
pubmed: 26772647
Am J Respir Crit Care Med. 2011 Aug 15;184(4):414-20
pubmed: 21562134
Cancer Res. 1999 Jul 15;59(14):3317-20
pubmed: 10416585
Ann N Y Acad Sci. 1991;624:339-40
pubmed: 2064241
Proc Am Thorac Soc. 2007 Dec;4(8):669-70
pubmed: 18073399