Modulation of Human Memory by Deep Brain Stimulation of the Entorhinal-Hippocampal Circuitry.
deep brain stimulation
entorhinal cortex
hippocampus
memory
neuromodulation
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
22 04 2020
22 04 2020
Historique:
received:
07
11
2019
revised:
13
01
2020
accepted:
27
01
2020
entrez:
24
4
2020
pubmed:
24
4
2020
medline:
12
8
2020
Statut:
ppublish
Résumé
Neurological disorders affecting human memory present a major scientific, medical, and societal challenge. Direct or indirect deep brain stimulation (DBS) of the entorhinal-hippocampal system, the brain's major memory hub, has been studied in people with epilepsy or Alzheimer's disease, intending to enhance memory performance or slow memory decline. Variability in the spatiotemporal parameters of stimulation employed to date notwithstanding, it is likely that future DBS for memory will employ closed-loop, nuanced approaches that are synergistic with native physiological processes. The potential for editing human memory-decoding, enhancing, incepting, or deleting specific memories-suggests exciting therapeutic possibilities but also raises considerable ethical concerns.
Identifiants
pubmed: 32325058
pii: S0896-6273(20)30147-1
doi: 10.1016/j.neuron.2020.02.024
pmc: PMC7347298
mid: NIHMS1568676
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
218-235Subventions
Organisme : NINDS NIH HHS
ID : R01 NS084017
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS108930
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests I.F. holds intellectual property in the field of deep brain stimulation assigned to the Regents of the University of California.
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