Melt Amorphisation of Orlistat with Mesoporous Silica Using a Supercritical Carbon Dioxide: Effects of Pressure, Temperature, and Drug Loading Ratio and Comparison with Other Conventional Amorphisation Methods.

dissolution melt-amorphisation mesoporous silica orlistat supercritical carbon dioxide

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
20 Apr 2020
Historique:
received: 26 03 2020
revised: 14 04 2020
accepted: 18 04 2020
entrez: 25 4 2020
pubmed: 25 4 2020
medline: 25 4 2020
Statut: epublish

Résumé

The aim of this work was to develop an amorphous orlistat-loaded mesoporus silica formulation using the melt-amorphisation by supercritical fluid (MA-SCF) and to investigate the effects of pressure and temperature on the pharmaceutical properties of the developed formulation. In addition, the effect of orlistat mass ratio to the mesoporus silica was also evaluated. The carbon dioxide was used as a supercritical fluid, and Neusilin

Identifiants

pubmed: 32326103
pii: pharmaceutics12040377
doi: 10.3390/pharmaceutics12040377
pmc: PMC7238234
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : National Research Foundation of Korea
ID : 2020R1A2C4002166
Organisme : National Research Foundation of Korea
ID : 2019R1F1A1056350
Organisme : National Research Foundation of Korea
ID : University-Centered Labs-2018R1A6A1A03023718

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Auteurs

Heejun Park (H)

College of Pharmacy, Pusan National University, 63 Busandaehak-ro, Geumjeong-gu, Busan 46241, Korea.

Kwang-Ho Cha (KH)

Yonsei Institute of Pharmaceutical Sciences & College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.

Seung Hyeon Hong (SH)

Yonsei Institute of Pharmaceutical Sciences & College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.

Sharif Md Abuzar (SM)

Yonsei Institute of Pharmaceutical Sciences & College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.

Eun-Sol Ha (ES)

College of Pharmacy, Pusan National University, 63 Busandaehak-ro, Geumjeong-gu, Busan 46241, Korea.

Jeong-Soo Kim (JS)

Dong-A ST Co. Ltd., Giheung-gu, Yongin, Gyeonggi 446-905, Korea.

Min-Soo Kim (MS)

College of Pharmacy, Pusan National University, 63 Busandaehak-ro, Geumjeong-gu, Busan 46241, Korea.

Sung-Joo Hwang (SJ)

Yonsei Institute of Pharmaceutical Sciences & College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea.

Classifications MeSH