Correlation of PKM2 and CD44 Protein Expression with Poor Prognosis in Platinum-Treated Epithelial Ovarian Cancer: A Retrospective Study.
CD44
PKM2
ovarian cancer
platinum-resistance
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
20 Apr 2020
20 Apr 2020
Historique:
received:
09
03
2020
revised:
14
04
2020
accepted:
16
04
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
25
4
2020
Statut:
epublish
Résumé
CD44, a surface marker for cancer stem cells, interacts with PKM2, a key regulator of aerobic glycolysis, and enhances the glycolytic phenotype of cancer cells leading to antioxidant protection and macromolecules' synthesis. To clarify the clinical importance of this "cross-talk" as a mechanism of drug resistance, we assessed the expression both of PKM2 and of CD44 in cancer cells of patients with epithelial ovarian cancer (EOC) treated with platinum-based treatment. One hundred and seventy-one patients with EOC were assessed for PKM2mRNA expression and PKM2 and CD44 proteins detection. Associations with progression-free survival (PFS) and overall survival (OS) were assessed with Kaplan-Meier and adjusted Cox regression models. PKM2mRNA and protein as well as CD44 protein were detectable in the majority of patients. Positive correlation between PKM2 and CD44 protein expression was observed (Spearman rho = 0.2,
Identifiants
pubmed: 32326107
pii: cancers12041013
doi: 10.3390/cancers12041013
pmc: PMC7225941
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Ann Oncol. 2005 Jul;16(7):1116-22
pubmed: 15928071
Nat Rev Cancer. 2003 Jul;3(7):502-16
pubmed: 12835670
Br J Cancer. 2014 Oct 28;111(9):1757-64
pubmed: 25233397
J Natl Cancer Inst. 2000 May 3;92(9):699-708
pubmed: 10793106
Int J Mol Sci. 2011 Jan 31;12(2):1009-29
pubmed: 21541039
Science. 2011 Dec 2;334(6060):1278-83
pubmed: 22052977
Oncologia. 1956;9(2):75-83
pubmed: 13335077
Clin Cancer Res. 2009 Jun 1;15(11):3827-33
pubmed: 19435835
Nature. 2012 Sep 27;489(7417):511-2
pubmed: 23018962
Semin Oncol. 2006 Apr;33(2 Suppl 6):S12-6
pubmed: 16716798
Elife. 2019 Jul 02;8:
pubmed: 31264961
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Mol Cell. 2014 Mar 6;53(5):700-9
pubmed: 24606918
J Natl Cancer Inst. 2003 Sep 3;95(17):1320-9
pubmed: 12953086
Oncotarget. 2017 Nov 20;8(66):110656-110670
pubmed: 29299177
Nature. 2008 Mar 13;452(7184):230-3
pubmed: 18337823
Int J Cancer. 2004 Feb 10;108(4):532-9
pubmed: 14696117
Nature. 2008 Mar 13;452(7184):181-6
pubmed: 18337815
Nat Chem Biol. 2012 Oct;8(10):839-47
pubmed: 22922757
CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29
pubmed: 22237781
Front Oncol. 2019 Feb 06;9:39
pubmed: 30788285
Int J Gynaecol Obstet. 2009 Apr;105(1):3-4
pubmed: 19322933
J Hematol Oncol. 2018 May 10;11(1):64
pubmed: 29747682
Oncotarget. 2017 Jul 6;8(35):59950-59964
pubmed: 28938696
Med Sci Monit. 2018 May 12;24:3103-3112
pubmed: 29752805
Cancer Res. 1986 Aug;46(8 Suppl):4244s-4248s
pubmed: 3524805
Clin Cancer Res. 2012 Oct 15;18(20):5554-61
pubmed: 23071357
Cell. 2011 May 27;145(5):732-44
pubmed: 21620138
Semin Cancer Biol. 2005 Aug;15(4):300-8
pubmed: 15908230
J Cancer Res Ther. 2018 Sep;14(Supplement):S616-S621
pubmed: 30249877
Am Fam Physician. 1999 Jun;59(11):3083-92
pubmed: 10392591
Nat Cell Biol. 2012 Dec;14(12):1295-304
pubmed: 23178880
Nat Rev Cancer. 2007 Aug;7(8):573-84
pubmed: 17625587
Biomolecules. 2015 Nov 11;5(4):3051-66
pubmed: 26569327
Nature. 2017 Sep 20;550(7674):142
pubmed: 28953868
Mol Cancer Res. 2017 Jan;15(1):78-92
pubmed: 27758876
N Engl J Med. 2004 Dec 9;351(24):2519-29
pubmed: 15590954
Cancer Res. 2012 Mar 15;72(6):1438-48
pubmed: 22293754
Cell. 2014 Aug 28;158(5):1210
pubmed: 28917293
PLoS One. 2011 Jan 20;6(1):e15980
pubmed: 21283802
Oncotarget. 2017 Jul 4;8(27):44171-44185
pubmed: 28498807
N Engl J Med. 1996 Jan 4;334(1):1-6
pubmed: 7494563
J Craniofac Surg. 2002 Jan;13(1):85-9
pubmed: 11887001
Mol Cancer. 2018 Feb 19;17(1):35
pubmed: 29455645
J Cancer Res Clin Oncol. 2011 Jan;137(1):65-72
pubmed: 20336315
Mol Cancer Ther. 2009 Apr;8(4):771-8
pubmed: 19372549
Lancet. 2002 Dec 21-28;360(9350):2086-7; author reply 2088
pubmed: 12504453
Mol Cell. 2012 Mar 9;45(5):598-609
pubmed: 22306293
Int J Gynaecol Obstet. 2006 Nov;95 Suppl 1:S161-92
pubmed: 17161157
Science. 1956 Feb 24;123(3191):309-14
pubmed: 13298683