Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs.
PROTACs
SNIPERs
chemical protein degradation
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
21 Apr 2020
21 Apr 2020
Historique:
received:
24
03
2020
revised:
17
04
2020
accepted:
19
04
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
25
4
2020
Statut:
epublish
Résumé
New therapeutic modalities are needed to address the problem of pathological but undruggable proteins. One possible approach is the induction of protein degradation by chimeric drugs composed of a ubiquitin ligase (E3) ligand coupled to a ligand for the target protein. This article reviews chimeric drugs that decrease the level of specific proteins such as proteolysis targeting chimeric molecules (PROTACs) and specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs), which target proteins for proteasome-mediated degradation. We cover strategies for increasing the degradation activity induced by small molecules, and their scope for application to undruggable proteins.
Identifiants
pubmed: 32326273
pii: ph13040074
doi: 10.3390/ph13040074
pmc: PMC7243126
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science
ID : 18H05502
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Bioorg Med Chem Lett. 2018 Feb 15;28(4):707-710
pubmed: 29366651
Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11778-83
pubmed: 18697935
Cancer Res. 2006 Aug 15;66(16):8100-8
pubmed: 16912187
Science. 2000 May 5;288(5467):874-7
pubmed: 10797013
Nat Rev Drug Discov. 2012 Feb 01;11(2):109-24
pubmed: 22293567
Bioorg Med Chem Lett. 2012 Jul 1;22(13):4453-7
pubmed: 22658364
Comput Struct Biotechnol J. 2019 Jan 25;17:160-176
pubmed: 30788082
Structure. 1994 Dec 15;2(12):1241-58
pubmed: 7704533
Bioorg Med Chem. 2020 Jan 1;28(1):115175
pubmed: 31767406
Genes Dev. 1999 Feb 1;13(3):239-52
pubmed: 9990849
PLoS One. 2008 Jan 23;3(1):e1487
pubmed: 18213395
Science. 2011 Oct 21;334(6054):376-80
pubmed: 22021857
Nature. 1988 Jan 14;331(6152):192-4
pubmed: 3277060
Bioorg Med Chem Lett. 2008 Nov 15;18(22):5904-8
pubmed: 18752944
Nat Rev Drug Discov. 2017 Feb;16(2):101-114
pubmed: 27885283
J Biol Chem. 1988 Jul 5;263(19):9326-32
pubmed: 2837484
J Biol Chem. 1983 Jul 10;258(13):8206-14
pubmed: 6305978
Molecules. 2019 Sep 08;24(18):
pubmed: 31500395
Bioorg Med Chem Lett. 2016 Jun 1;26(11):2655-8
pubmed: 27086122
Bioorg Med Chem Lett. 2017 Nov 15;27(22):4985-4988
pubmed: 29050782
Mol Cell. 2011 Jun 10;42(5):637-49
pubmed: 21658604
Science. 1989 Mar 24;243(4898):1576-83
pubmed: 2538923
Front Mol Neurosci. 2014 Sep 29;7:77
pubmed: 25324717
ACS Chem Biol. 2008 Jun 20;3(6):373-82
pubmed: 18533659
Cell Res. 2011 Jan;21(1):71-85
pubmed: 21173796
J Am Chem Soc. 2004 Mar 31;126(12):3748-54
pubmed: 15038727
Mol Cell Biol. 1995 Mar;15(3):1265-73
pubmed: 7862120
Molecules. 2018 Aug 06;23(8):
pubmed: 30082609
Biochem Biophys Res Commun. 1991 Aug 30;179(1):259-65
pubmed: 1652951
Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11530-11533
pubmed: 28703441
Org Biomol Chem. 2015 Oct 14;13(38):9746-50
pubmed: 26338696
Clin Cancer Res. 2000 May;6(5):1796-803
pubmed: 10815900
Nature. 1995 Dec 14;378(6558):681-9
pubmed: 7501014
Bioorg Med Chem Lett. 2008 Jun 1;18(11):3354-8
pubmed: 18448338
Biochem Biophys Res Commun. 1978 Apr 28;81(4):1100-5
pubmed: 666810
Drug Discov Today. 2003 Dec 1;8(23):1067-77
pubmed: 14693466
J Natl Cancer Inst. 2003 Apr 16;95(8):605-10
pubmed: 12697853
J Biol Chem. 2008 Apr 4;283(14):8961-8
pubmed: 18230607
J Biol Chem. 2017 Mar 17;292(11):4556-4570
pubmed: 28154167
Physiol Rev. 2002 Apr;82(2):373-428
pubmed: 11917093
J Antibiot (Tokyo). 1976 Jan;29(1):97-9
pubmed: 931798
J Am Chem Soc. 2013 Apr 24;135(16):6092-9
pubmed: 23544844
Cancer Sci. 2013 Nov;104(11):1492-8
pubmed: 23992566
Biochem J. 2017 Mar 15;474(7):1127-1147
pubmed: 28298557
Nature. 1962 Aug 18;195:701-2
pubmed: 13900478
Bioorg Med Chem. 2008 Apr 15;16(8):4685-98
pubmed: 18313309
Bioorg Med Chem. 2011 May 15;19(10):3229-41
pubmed: 21515062
EMBO J. 2002 Aug 1;21(15):4037-48
pubmed: 12145204
Annu Rev Biochem. 2009;78:399-434
pubmed: 19489725
Nature. 1998 Feb 19;391(6669):806-11
pubmed: 9486653
Annu Rev Biochem. 2017 Jun 20;86:129-157
pubmed: 28375744
J Biol Chem. 2018 May 4;293(18):6776-6790
pubmed: 29545311
Bioorg Med Chem. 2016 Jul 15;24(14):3144-8
pubmed: 27236416
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8554-9
pubmed: 11438690
Nat Chem Biol. 2015 Aug;11(8):611-7
pubmed: 26075522
ACS Chem Biol. 2015 Aug 21;10(8):1770-7
pubmed: 26035625
J Med Chem. 2018 Jan 25;61(2):543-575
pubmed: 28594553
FEBS Lett. 2011 Apr 20;585(8):1147-52
pubmed: 21414315
ACS Chem Biol. 2009 Jul 17;4(7):557-66
pubmed: 19492850
Science. 2008 Aug 15;321(5891):960-4
pubmed: 18703739
J Am Chem Soc. 2010 Apr 28;132(16):5820-6
pubmed: 20369832
Sci Rep. 2018 Sep 10;8(1):13549
pubmed: 30202081
Cell. 1984 May;37(1):43-55
pubmed: 6327059
ACS Med Chem Lett. 2017 Sep 14;8(10):1042-1047
pubmed: 29057048
Nat Rev Drug Discov. 2002 Sep;1(9):727-30
pubmed: 12209152
Blood. 1981 Jun;57(6):1000-4
pubmed: 6939451
Bioorg Med Chem Lett. 2012 Feb 15;22(4):1793-6
pubmed: 22277276
Bioorg Med Chem. 2011 Nov 15;19(22):6768-78
pubmed: 22014751
Chem Biol. 2015 Jun 18;22(6):755-63
pubmed: 26051217
Bioorg Med Chem Lett. 2016 Oct 15;26(20):4865-4869
pubmed: 27666635
Mol Pharmacol. 2017 Mar;91(3):159-166
pubmed: 27965304
Prostate. 2007 Jun 1;67(8):900-6
pubmed: 17440969
Science. 2015 Jun 19;348(6241):1376-81
pubmed: 25999370
J Med Chem. 2018 Jan 25;61(2):576-582
pubmed: 28460164
Nat Cell Biol. 2016 May 27;18(6):579-86
pubmed: 27230526
Nat Rev Mol Cell Biol. 2014 Aug;15(8):503-8
pubmed: 25027653
Cell. 2000 Oct 13;103(2):351-61
pubmed: 11057907
Annu Rev Biochem. 1998;67:425-79
pubmed: 9759494