Fetuin-A and Fetuin-B in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and Meta-Regression.
fetuin-A
fetuin-B
meta-analysis
meta-regression
non-alcoholic fatty liver disease
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
15 04 2020
15 04 2020
Historique:
received:
25
02
2020
revised:
08
04
2020
accepted:
09
04
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
25
9
2020
Statut:
epublish
Résumé
The magnitude of the effect of fetuin-A and fetuin-B on non-alcoholic fatty liver disease (NAFLD) remains undefined. Therefore, the aim of this study was to synthesize previous findings to obtain a reliable estimation of this relationship. This study was registered in PROSPERO with the number CRD42019126314. Studies published not later than March 2019, examining the relationship between fetuin-A, fetuin-B, and NAFLD, were identified by a systematic search in the electronic databases of the Web of Science, PubMed, Embase, and Cochrane Library. Pooled estimates of standardized mean difference (SMD), calculated using the random-effects model in a meta-analysis, were applied to estimate the strength of the association between fetuin-A, fetuin-B, and NAFLD. Thirty publications were identified and analyzed based on specified inclusion criteria. Collectively, they consisted of 3800 NAFLD participants and 3614 controls. Compared with the controls, significant higher values of the fetuin-A (SMD = 0.83, 95% CI: 0.59 to 1.07, Z = 6.82,
Identifiants
pubmed: 32326594
pii: ijerph17082735
doi: 10.3390/ijerph17082735
pmc: PMC7215562
pii:
doi:
Substances chimiques
Biomarkers
0
Fetuin-B
0
alpha-2-HS-Glycoprotein
0
alpha-Fetoproteins
0
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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