Resistance to carbapenems and other antibiotics in

Animals Carbapenems / pharmacology Drug Resistance, Bacterial / genetics Europe Klebsiella pneumoniae / drug effects Seals, Earless / microbiology Water Pollution
antimicrobials bacteriology marine mammals molecular biology resistance

Journal

The Veterinary record
ISSN: 2042-7670
Titre abrégé: Vet Rec
Pays: England
ID NLM: 0031164

Informations de publication

Date de publication:
22 Aug 2020
Historique:
received: 01 05 2019
revised: 10 09 2019
accepted: 29 01 2020
pubmed: 25 4 2020
medline: 11 11 2020
entrez: 25 4 2020
Statut: ppublish

Résumé

The beta-lactamase enzyme OXA-48 has spread widely in recent years in Enterobacteriaceae associated with man, disseminated primarily on incompatibility group L/M plasmids. OXA-48 confers resistance to carbapenems, important antimicrobials for treating highly resistant bacterial infections in humans. This enzyme has rarely been detected in bacteria from animals. Furthermore, the use of carbapenem compounds is not permitted in food-producing animals in Europe and to our knowledge has not been reported in food-producing animals globally. Bacterial isolates from lesions in stranded, free-living, juvenile common seals ( Here, we report the detection of Evidence is accruing that marine mammals may be infected with bacteria originating from anthropogenic sources, such as human sewage, contaminating the environment.

Sections du résumé

BACKGROUND BACKGROUND
The beta-lactamase enzyme OXA-48 has spread widely in recent years in Enterobacteriaceae associated with man, disseminated primarily on incompatibility group L/M plasmids. OXA-48 confers resistance to carbapenems, important antimicrobials for treating highly resistant bacterial infections in humans. This enzyme has rarely been detected in bacteria from animals. Furthermore, the use of carbapenem compounds is not permitted in food-producing animals in Europe and to our knowledge has not been reported in food-producing animals globally.
METHODS METHODS
Bacterial isolates from lesions in stranded, free-living, juvenile common seals (
RESULTS RESULTS
Here, we report the detection of
CONCLUSION CONCLUSIONS
Evidence is accruing that marine mammals may be infected with bacteria originating from anthropogenic sources, such as human sewage, contaminating the environment.

Identifiants

DOI: 10.1136/vr.105440 PMID: 32327551
pubmed: 32327551
pii: vr.105440
doi: 10.1136/vr.105440
doi:

Substances chimiques

Carbapenems 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

154

Informations de copyright

© British Veterinary Association 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

James Paul Duff (JP)

Animal Plant and Health Agency (APHA), Diseases of Wildlife Scheme, APHA Penrith Veterinary Investigation Centre, Penrith, UK paul.duff@apha.gov.uk.
ORCID: 0000-0002-7521-8923

Manal AbuOun (M)

Department of Bacteriology, Animal and Plant Health Agency, Weybridge, UK.

Steve Bexton (S)

RSPCA Norfolk Wildlife Hospital, Kings Lynn, UK.

Jon Rogers (J)

Animal and Plant Health Agency Bury St Edmunds Veterinary Investigation Centre, Bury St Edmunds, UK.

Jane Turton (J)

National Infection Service, Public Health England, London, UK.

Neil Woodford (N)

National Infection Service, Public Health England, London, UK.

Richard Irvine (R)

Surveillance Intelligence Unit, Animal and Plant Health Agency, Weybridge, UK.

Muna Anjum (M)

Department of Bacteriology, Animal and Plant Health Agency, Weybridge, UK.

Christopher Teale (C)

Animal Plant and Health Agency Shrewsbury Veterinary Investigation Centre, Shrewsbury, UK.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Resistance to carbapenems and other antibiotics in
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Resistance to carbapenems and other antibiotics in
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Resistance to carbapenems and other antibiotics in
questionsmedicales.fr › Régions géographiques › Europe › Resistance to carbapenems and other antibiotics in
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae › Resistance to carbapenems and other antibiotics in
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Phoques › Resistance to carbapenems and other antibiotics in
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'eau › Resistance to carbapenems and other antibiotics in