Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy.
RNA binding protein
hippocampus
microglia
neurodegeneration
neuroinflammation
tauopathy
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
01
2020
accepted:
12
03
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
25
4
2020
Statut:
epublish
Résumé
Neuroinflammatory processes play an integral role in the exacerbation and progression of pathology in tauopathies, a class of neurodegenerative disease characterized by aggregation of hyperphosphorylated tau protein. The RNA binding protein (RBP) T-cell Intracellular Antigen 1 (TIA1) is an important regulator of the innate immune response in the periphery, dampening cytotoxic inflammation and apoptosis during cellular stress, however, its role in neuroinflammation is unknown. We have recently shown that TIA1 regulates tau pathophysiology and toxicity in part through the binding of phospho-tau oligomers into pathological stress granules, and that haploinsufficiency of TIA1 in the P301S mouse model of tauopathy results in reduced accumulation of toxic tau oligomers, pathologic stress granules, and the development of downstream pathological features of tauopathy. The putative role of TIA1 as a regulator of the peripheral immune response led us to investigate the effects of TIA1 on neuroinflammation in the context of tauopathy, a chronic stressor in the neural environment. Here, we evaluated indicators of neuroinflammation including; reactive microgliosis and phagocytosis, pro-inflammatory cytokine release, and oxidative stress in hippocampal neurons and glia of wildtype and P301S transgenic mice expressing TIA1
Identifiants
pubmed: 32327969
doi: 10.3389/fnins.2020.00285
pmc: PMC7161592
doi:
Types de publication
Journal Article
Langues
eng
Pagination
285Subventions
Organisme : NIH HHS
ID : S10 OD023663
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG064932
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG056318
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050471
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES020395
Pays : United States
Informations de copyright
Copyright © 2020 LeBlang, Medalla, Nicoletti, Hays, Zhao, Shattuck, Cruz, Wolozin and Luebke.
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