Model-Based Weaning Tests for VA-ECLS Therapy.
Journal
Computational and mathematical methods in medicine
ISSN: 1748-6718
Titre abrégé: Comput Math Methods Med
Pays: United States
ID NLM: 101277751
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
06
2019
revised:
14
02
2020
accepted:
23
03
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
23
3
2021
Statut:
epublish
Résumé
Venoarterial extracorporeal life support (VA-ECLS) is used in ICUs (intensive care units) for the most extreme presentations of acute and severe cardiogenic shock, and one of the main issues the clinicians have to deal with is the weaning from VA-ECLS. In this study, a patient-specific model of the cardiovascular system connected to a VA-ECLS is built to improve the understanding of this complex system. Pig experiments are performed to validate the model, and the results are quite promising since the mean difference between experimental data and simulation is smaller than 5% for all the hemodynamic quantities. It is also a major objective of this paper to provide a proof-of-concept analysis that model-based approaches could improve the weaning strategy for VA-ECLS therapy.
Identifiants
pubmed: 32328151
doi: 10.1155/2020/4503919
pmc: PMC7165357
doi:
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
4503919Informations de copyright
Copyright © 2020 Simon Habran et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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