Occult Thyroid Carcinoma without Malignant Thyroid Gland Findings during Preoperative Examination: Report of Three Cases.
Journal
Case reports in endocrinology
ISSN: 2090-6501
Titre abrégé: Case Rep Endocrinol
Pays: United States
ID NLM: 101576457
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
12
2019
accepted:
25
03
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
25
4
2020
Statut:
epublish
Résumé
Occult thyroid carcinoma preceded by clinical manifestations and findings from extrathyroidal tumors is rare. The lack of malignant findings in the thyroid during the preoperative examination makes diagnosis difficult. We encountered a 71-year-old man with a primary ectopic thyroid carcinoma causing superior vena cava syndrome. Although no malignant findings were found in the thyroid gland, biopsy of bone metastases led to the diagnosis of thyroid cancer. HE staining of bone metastases revealed nuclear features of papillary carcinoma, and immunostaining was positive for thyroglobulin and PAX-8. The second case involved an 84-year-old man with a mediastinal tumor and suspected thyroid cancer because of high thyroglobulin levels in blood. The pathological tumor finding was papillary thyroid cancer. The last case was that of a 56-year-old woman lacking preoperative thyroid examination malignant findings, but with cervical lymph node metastasis. The thyroglobulin level of the lymph node puncture fluid was useful for preoperative diagnosis. We performed total thyroidectomy plus bilateral modified neck dissection. Pathology revealed a 1 mm papillary carcinoma in the left lobe. All of these cases were difficult to diagnose. However, we combined the results of various tests such as radiographic imaging, blood tests, and immunohistological tests to diagnose our patients.
Identifiants
pubmed: 32328315
doi: 10.1155/2020/4249067
pmc: PMC7171659
doi:
Types de publication
Case Reports
Langues
eng
Pagination
4249067Informations de copyright
Copyright © 2020 Soji Toda et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this article.
Références
World J Surg. 2008 Sep;32(9):1955-60
pubmed: 18594906
Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):784-91
pubmed: 19240234
Head Neck. 1999 Jul;21(4):370-4
pubmed: 10376759
World J Surg. 2005 Apr;29(4):483-5
pubmed: 15776292
Int J Clin Exp Pathol. 2014 Jul 15;7(8):5210-4
pubmed: 25197399
Thyroid. 2016 Jan;26(1):1-133
pubmed: 26462967
Endocrinol Diabetes Metab Case Rep. 2019 Jun 30;2019(1):
pubmed: 31368678
Acta Otorhinolaryngol Ital. 2009 Dec;29(6):296-304
pubmed: 20463833